Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 2
KLF15 Antibody (PA5-23324) in IHC (P)
Immunohistochemical analysis of KLF15 in Tissue section of human liver. Samples were incubated in KLF15 polyclonal antibody (Product # PA5-23324) using a dilution of 1:100. The antibody generated strong cytoplasmic staining with some nuclear signal in the hepatocytes, while in Kupffer cells, the signal was mainly nuclear and was most intense among all cell types.
Product Details
PA5-23324
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide made to an internal portion of the human KLF15 protein (between amino acids 100-200) [UniProt Q9UIH9]
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2540848
Target Information
KLF15 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. A transcriptional activator, KLF15 binds to the GA element of the CLCNKA promoter and may help to regulate the strict tissue and nephron segment-specific expression of CLCNKA and CLCNKB channel genes. It plays an essential role in adipogenesis in cells through its regulation of PPARG expression. Reports suggest that KLF15 is an inhibitor of cardiac hypertrophy and functions in a pathway, regulating the cardiac response to hemodynamic stress, and regulates mitochondrial acetyl-CoA synthase expression in skeletal muscle. KLF15 may also act as a transcriptional repressor of the rhodopsin and IRBP promoters in the retina, and is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells. It is highly expressed in liver, followed by heart, skeletal muscle, and kidney but not expressed in bone marrow or lymphoid tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Cardiovascular Krueppel-like factor; DKFZp779M1320; Kidney-enriched krueppel-like factor; kidney-enriched Kruppel-like factor; KKLF protein; Krueppel-like factor 15; Kruppel-like factor 15
Gene Aliases: 1810013I09Rik; AV048136; AW494632; BOS_21222; CKLF; KKLF; KLF15
UniProt ID: (Human) Q9UIH9, (Mouse) Q9EPW2
Entrez Gene ID: (Bovine) 407241, (Human) 28999, (Mouse) 66277
transcription, DNA-templated
regulation of transcription, DNA-templated
glial cell differentiation
regulation of gene expression
cardiac muscle hypertrophy in response to stress
glucose transport
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
glomerular visceral epithelial cell differentiation
negative regulation of peptidyl-lysine acetylation
transcription from RNA polymerase II promoter
cellular response to peptide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support