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Product Details
PA5-70374
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N-terminal region of KLF15
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2691026
Product Specific Information
This target displays homology in the following species: Cow: 92%; Dog: 93%; Guinea Pig: 93%; Horse: 91%; Human: 100%; Mouse: 93%; Rat: 100%
Target Information
KLF15 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. A transcriptional activator, KLF15 binds to the GA element of the CLCNKA promoter and may help to regulate the strict tissue and nephron segment-specific expression of CLCNKA and CLCNKB channel genes. It plays an essential role in adipogenesis in cells through its regulation of PPARG expression. Reports suggest that KLF15 is an inhibitor of cardiac hypertrophy and functions in a pathway, regulating the cardiac response to hemodynamic stress, and regulates mitochondrial acetyl-CoA synthase expression in skeletal muscle. KLF15 may also act as a transcriptional repressor of the rhodopsin and IRBP promoters in the retina, and is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells. It is highly expressed in liver, followed by heart, skeletal muscle, and kidney but not expressed in bone marrow or lymphoid tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiovascular Krueppel-like factor; DKFZp779M1320; KKLF protein; Krueppel-like factor 15
Gene Aliases: 1810013I09Rik; AV048136; AW494632; CKLF; KKLF; Klf15
UniProt ID: (Mouse) Q9EPW2
Entrez Gene ID: (Mouse) 66277
transcription, DNA-templated
regulation of transcription, DNA-templated
glial cell differentiation
regulation of gene expression
cardiac muscle hypertrophy in response to stress
glucose transport
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
glomerular visceral epithelial cell differentiation
negative regulation of peptidyl-lysine acetylation
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