Proteintech

KLF6 Polyclonal Antibody

KLF6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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KLF6 Antibody (14716-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human testis using 14716-1-AP (KLF6 antibody) at dilution of 1:200 (under 40x lens).

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Product Details

14716-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLF6 Fusion Protein Ag6440 (1-283 aa encoded by BC000311)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody raise against the full length of KLF6 gene of human origin, and can recognize both of KLF6, included KLF6 (~32 kDa), p-KLF6(~35-46 kDa). Otherwise, there may be a non-specific band(50 kDa) shown.

Immunogen sequence: MDVLPMCSI FQELQIVHET GYFSALPSLE EYWQQTCLEL ERYLQSEPCY VSASEIKFDS QEDLWTKIIL AREKKEESEL KISSSPPEDT LISPSFCYNL ETNSLNSDVS SESSDSSEEL SPTAKFTSDP IGEVLVSSGK LSSSVTSTPP SSPELSREPS QLWGCVPGEL PSPGKVRSGT SGKPGDKGNG DASPDGRRRV HRCHFNGCRK VYTKSSHLKA HQRTHTGEKP YRCSWEGCEW RFARSDELTR HFRKHTGAKP FKCSHCDRCF SRSDHLALHM KRHL (1-283 aa encoded by BC000311)

Target Information

This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer.

Biochemical and biophysical research communications

Zhou J,Yan X,Liu Y,Yang J

Sun Apr 02 00:00:00 UTC 2023

MicroRNA-22-3p Regulates the Apoptosis of Lens Epithelial Cells Through Targeting KLF6 in Diabetic Cataracts.

Translational vision science & technology

Yin X,Chen L,Shen J,Bi Z,Chen C,Zhao X,Liu S,Li Y

Mon May 01 00:00:00 UTC 2023

Revealing Potential Spinal Cord Injury Biomarkers and Immune Cell Infiltration Characteristics in Mice.

Frontiers in genetics

Cao L,Li Q

Sat Jul 16 00:00:00 UTC 2022

MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.

Bioengineered

Zhou S,Li J,Zhang X,Xiong W

Sun May 01 00:00:00 UTC 2022

Bone marrow mesenchymal stem cell-derived extracellular vesicles containing miR-181d protect rats against renal fibrosis by inhibiting KLF6 and the NF-κB signaling pathway.

Cell death & disease

Wang SJ,Qiu ZZ,Chen FW,Mao AL,Bai JC,Hong YJ,Zhang ZP,Zhu WA,Zhang ZW,Zhou H

Tue Jun 07 00:00:00 UTC 2022

Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis.

Cell death & disease

Sun S,Chen H,Sun L,Wang M,Wu X,Xiao ZJ

Thu Jul 30 00:00:00 UTC 2020

MiR-181d-5p Targets KLF6 to Improve Ischemia/Reperfusion-Induced AKI Through Effects on Renal Function, Apoptosis, and Inflammation.

Frontiers in physiology

Zhang Y,Li C,Guan C,Zhou B,Wang L,Yang C,Zhen L,Dai J,Zhao L,Jiang W,Xu Y

Mon Sep 28 00:00:00 UTC 2020

MiR-181d-5p Targets KLF6 to Improve Ischemia/Reperfusion-Induced AKI Through Effects on Renal Function, Apoptosis, and Inflammation.

Frontiers in physiology

Zhang Y,Li C,Guan C,Zhou B,Wang L,Yang C,Zhen L,Dai J,Zhao L,Jiang W,Xu Y

Mon Sep 28 00:00:00 UTC 2020

Salvia miltiorrhiza bunge exerts anti-oxidative effects through inhibiting KLF10 expression in vascular smooth muscle cells exposed to high glucose.

Journal of ethnopharmacology

Zhou J,Zhang L,Zheng B,Zhang L,Qin Y,Zhang X,Yang Z,Nie Z,Yang G,Yu J,Wen J

Sun Nov 15 00:00:00 UTC 2020

Artesunate induces mitochondria-mediated apoptosis of human retinoblastoma cells by upregulating Kruppel-like factor 6.

Cell death & disease

Yang Y,Wu N,Wu Y,Chen H,Qiu J,Qian X,Zeng J,Chiu K,Gao Q,Zhuang J

Wed Nov 13 00:00:00 UTC 2019

Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.

Development (Cambridge, England)

Suzuki T,Kikuguchi C,Nishijima S,Nagashima T,Takahashi A,Okada M,Yamamoto T

Fri Feb 15 00:00:00 UTC 2019

The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.

Nutrients

Wang Y,Zhang XN,Xie WH,Zheng YX,Cao JP,Cao PR,Chen QJ,Li X,Sun CD

Tue Sep 27 00:00:00 UTC 2016

The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.

Nutrients

Wang Y,Zhang XN,Xie WH,Zheng YX,Cao JP,Cao PR,Chen QJ,Li X,Sun CD

Tue Sep 27 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: B-cell-derived protein 1; core promoter element binding protein; Core promoter element-binding protein; GC-rich binding factor; GC-rich sites-binding factor GBF; immediate early response, erythropoietin 1; Krueppel-like factor 6; Kruppel-like factor 6; Kruppel-like zinc finger protein Zf9; Proto-oncogene BCD1; protooncogene B-cell derived 1; suppression of tumorigenicity 12 (prostate); Suppressor of tumorigenicity 12 protein; Transcription factor Zf9

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Gene Aliases: Aa1017; AI448727; BCD1; C86813; CBA1; COPEB; CPBP; FM2; FM6; GBF; Ierepo1; Ierepo3; KLF6; PAC1; R75280; ST12; ZF9

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UniProt ID: (Human) Q99612

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Entrez Gene ID: (Human) 1316, (Mouse) 23849, (Rat) 58954

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Function(s)

double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding metal ion binding nucleic acid binding DNA binding

Process(es)

transcription, DNA-templated B cell differentiation wound healing positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cellular response to hydrogen peroxide cellular response to cycloheximide cellular response to peptide regulation of transcription, DNA-templated cytokine-mediated signaling pathway cellular response to organic cyclic compound

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KLF6 Polyclonal Antibody

KLF6 Antibody (14716-1-AP) in IHC (P)

Product Details

14716-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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