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Product Details
13905-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLHDC3 Fusion Protein Ag4879 (107-382 aa encoded by BC041793)
Conjugate
Form
Liquid
Concentration
0.52 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody specifically reacts with the 55 kDa KLHDC3 protein.
Immunogen sequence: MTPKGPAMC SMPLTSADCF SNDIHKLDTS TMTWTLICTK GSPARWRDFH SATMLGSHMY VFGGRADRFG PFHSNNEIYC NRIRVFDTRT EAWLDCPPTP VLPEGRRSHS AFGYNGELYI FGGYNARLNW HFHDLWKFNP VSFTWKKIEP KGKGPCPRRR QCCCIVGDKI VLFGGTSPSP EEGLGDEFDL IDHSDLHILD FSPSLKTLCK LAVIQYNLDQ SCLPHDIRWE LNAMTTNSNI SRPIVSSHG (107-382 aa encoded by BC041793)
Target Information
The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. The Kelch domain-containing protein 3 (KLHDC3), also designated PEAS, contains 5 Kelch repeats and may be involved in meiotic recombination process. The gene encoding KLHDC3 maps to chromosome 6, which contains around 1, 200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. KLHDC3 protein is mainly expressed in cytoplasm, also found in meiotic chromatin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Kelch domain-containing protein 3; protein Peas; RP1-20C7.3; Testis intracellular mediator protein
Gene Aliases: 1300011D16Rik; dJ20C7.3; KLHDC3; PEAS
UniProt ID: (Human) Q9BQ90, (Rat) Q6AYI2, (Mouse) Q8VEM9
Entrez Gene ID: (Human) 116138, (Rat) 363192, (Mouse) 71765
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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