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This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants.
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Protein Aliases: Kelch domain-containing protein 8A; S-delta-E1; Substitute for delta-EGFR expression 1
Gene Aliases: A630065K24Rik; KLHDC8A; RGD1305132
UniProt ID: (Human) Q8IYD2, (Mouse) Q91XA8
Entrez Gene ID: (Human) 55220, (Rat) 305096, (Mouse) 213417
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