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Proteintech
KLKB1 Polyclonal Antibody
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Product Details
27991-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLKB1 Fusion Protein Ag27491 (65-348 aa encoded by NM_000892)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antigen of this antibody just cover the heavy chain of KLKB1, so this antibody cannot recognize the light chain.
Immunogen sequence: MASSINDME KRFGCFLKDS VTGTLPKVHR TGAVSGHSLK QCGHQISACH RDIYKGVDMR GVNFNVSKVS SVEECQKRCT NNIRCQFFSY ATQTFHKAEY RNNCLLKYSP GGTPTAIKVL SNVESGFSLK PCALSEIGCH MNIFQHLAFS DVDVARVLTP DAFVCRTICT YHPNCLFFTF YTNVWKIESQ RNVCLLKTSE SGTPSSSTPQ ENTISGYSLL TCKRTLPEPC HSKIYPGVDF GGEELNVTFV KGVNVCQETC TKMIRCQFFT YSLLPEDCKE EKCKCF (65-348 aa encoded by NM _000892)
Target Information
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen, prostate specific; EC 3.4.21.34; Fletcher factor; kallikrein 3, plasma; kallikrein B plasma; kallikrein B, plasma (Fletcher factor) 1; Kininogenin; PKK; Plasma kallikrein; Plasma prekallikrein
Gene Aliases: APS; Kal-3; Kal3; Kalp1; KALP15; KLK3; KLKB1; Pk; PKK; PKKD; PPK; PSA
UniProt ID: (Human) P03952, (Mouse) P26262
Entrez Gene ID: (Human) 3818, (Rat) 25048, (Mouse) 16621
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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