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Product Details
PA5-21950
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide encompassing a sequence within the Intracellular domain of human KLRC4. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11155428
Product Specific Information
Recommended positive controls: 293T.
Predicted reactivity: Chimpanzee (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The KLRC4 (Killer Cell Lectin Like Receptor C4) gene encodes a member of the NKG2 family of receptors, which are expressed mostly on natural killer (NK) cells and some T lymphocytes. This gene is located on chromosome 12 and plays a key role in immune surveillance and the activation of NK cells. The KLRC4 protein, also known as NKG2F, interacts with other receptors such as KLRK1 (NKG2D) to recognize stress-induced ligands on potential target cells, thereby mediating their destruction. Variants and polymorphisms in KLRC4 have been investigated in various immune-related conditions, including their association with thyroid diseases and cancer.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: killer cell lectin-like receptor subfamily C, member 4; natual killer cell group 2-F; NK cell receptor F; NKG2-F type II integral membrane protein; NKG2-F-activating NK receptor
Gene Aliases: KLRC4; NKG2-F; NKG2F
UniProt ID: (Human) O43908
Entrez Gene ID: (Human) 8302
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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