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KMT2E Antibody (PA5-98614) in WB
Western Blot analysis of KMT2E using a KMT2E Polyclonal antibody (Product # PA5-98614) at a concentration of 3.1 µg/mL. Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate, NIH/3T3 whole cell lysate, 293T whole cell lysate, MCF-7 whole cell lysate, K562 whole cell lysate. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 80 kDa.
Product Details
PA5-98614
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Histone-lysine N-methyltransferase 2E protein (182-316AA)
Conjugate
Form
Liquid
Concentration
3.175 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2813227
Target Information
The mixed lineage leukemia (MLL) gene family comprise a group of Histone H3 lysine 4 (H3K4) methyltransferases within the larger SET1 family. The founding member MLL commonly undergoes translocations in infantile leukemia and displays increased expression in some adult myeloid leukemias. MLL2, also designated ALR, exists within a complex of proteins. MLL2 is important for mouse embryonic development and may be involved in adhesion-related cytoskeletal events affecting cell growth and survival. The MLL2 gene maps to the human locus 19q13.1, which is a frequent target of rearrangement or amplification in solid tumors. MLL3 or its paralogue MLL4 associate with activating signal cointegrator-2 (ASC-2), which regulates ligand-dependent H3K4 trimethylation and expression of LXR-target genes. MLL3 maps to a location on human chromosome 7 that is often deleted in myeloid disorders. MLL3 also exhibits higher expression in peripheral blood, placenta, pancreas, testis, and fetal thymus. MLL5 localizes to the nucleus and forms intranuclear protein complexes, which may regulate chromatin remodeling and cellular growth suppression. The gene encoding human MLL5 lies within chromosome band 7q22.3, a region deleted in cytogenetic aberrations of acute myeloid malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; Inactive histone-lysine N-methyltransferase 2E; Inactive lysine N-methyltransferase 2E; lysine (K)-specific methyltransferase 2E; lysine N-methyltransferase 2E; MGC70452; myeloid/lymphoid or mixed-lineage leukemia 5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); Myeloid/lymphoid or mixed-lineage leukemia protein 5; Myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog
Gene Aliases: 1810033J14Rik; 9530077A04Rik; D230038D11Rik; HDCMC04P; KMT2E; MLL5; NKp44L
UniProt ID: (Human) Q8IZD2, (Mouse) Q3UG20
Entrez Gene ID: (Human) 55904, (Mouse) 69188
neutrophil mediated immunity
DNA methylation
transcription, DNA-templated
cell cycle arrest
erythrocyte differentiation
positive regulation of granulocyte differentiation
neutrophil activation
positive regulation of transcription, DNA-templated
retinoic acid receptor signaling pathway
histone H3-K4 methylation
cellular response to retinoic acid
regulation of transcription, DNA-templated
cell cycle
chromatin modification
methylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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