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A suggested positive control is human liver tissue lysate.
PA5-21033 can be used with blocking peptide PEP-1147.
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Importin alpha Q1; Importin subunit alpha-3; importin subunit alpha-4; importin-alpha-Q1; karyopherin (importin) alpha 4; karyopherin alpha 4; karyopherin alpha 4 (importin alpha 3); Karyopherin subunit alpha-4; MGC12217; MGC26703; predicted role in nuclear import; Qip1; Qip1 protein
Gene Aliases: 1110058D08Rik; importin; IPOA3; KPNA4; QIP1; SRP3
UniProt ID: (Human) O00629, (Mouse) O35343
Entrez Gene ID: (Human) 3840, (Mouse) 16649, (Rat) 361959
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