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Recommended positive controls: 293T, HeLa, HepG2, Molt-4, Raji, A549.
Predicted reactivity: Chimpanzee (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Importin alpha Q1; Importin subunit alpha-3; importin subunit alpha-4; importin-alpha-Q1; karyopherin (importin) alpha 4; karyopherin alpha 4; karyopherin alpha 4 (importin alpha 3); Karyopherin subunit alpha-4; MGC12217; MGC26703; predicted role in nuclear import; Qip1; Qip1 protein
Gene Aliases: 1110058D08Rik; importin; IPOA3; KPNA4; QIP1; SRP3
UniProt ID: (Human) O00629, (Mouse) O35343
Entrez Gene ID: (Human) 3840, (Mouse) 16649, (Rat) 361959
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