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KPTN Polyclonal Antibody

KPTN Antibody in Immunocytochemistry (ICC/IF)

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KPTN Antibody (16094-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 16094-1-AP (KPTN antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

KPTN Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

16094-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KPTN Fusion Protein Ag8785 (79-436 aa encoded by BC009249)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EIVSIDTFN KSPPKRGLVV GITFIKDSGD KGSPFLNIYC DYEPGSEYNL DSIAQSCLNL ELQFTPFQLC HAEVQVGDQL ETVFLLSGND PAIHLYKENE GLHQFEEQPV ENLFPELTNL TSSVLWLDVH NFPGTSRRLS ALGCQSGYVR VAHVDQRSRE VLQMWSVLQD GPISRVIVFS LSAAKETKDR PLQDEYSVLV ASMLEPAVVY RDLLNRGLED QLLLPGSDQF DSVLCSLVTD VDLDGRPEVL VATYGQELLC YKYRGPESGL PEAQHGFHLL WQRSFSSPLL AMAHVDLTGD GLQELAVVSL KGVHILQHSL IQASELVLTR LRHQVEQRRR RLQGLEDGAG AGPAENAAS (79-436 aa encoded by BC009249)

Target Information

Kaptin, also named as KPTN and Actin-associated protein 2E4, originally isolated from human blood platelets and likely to be involved in the actin rearrangements occurring during activation. It plays a unique role in the actin rearrangements that accompany platelet activation and stereocilia formation. Kaptin is necessary for normal neuromorphogenesis. It may play a role in producing the sensory apparatus in hair cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing.

Nature cell biology

Yan G,Yang J,Li W,Guo A,Guan J,Liu Y

Mon May 01 00:00:00 UTC 2023

CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth.

Cell reports

Yin S,Liu L,Ball LE,Wang Y,Bedford MT,Duncan SA,Wang H,Gan W

Tue Apr 25 00:00:00 UTC 2023

Structure of the nutrient-sensing hub GATOR2.

Nature

Valenstein ML,Rogala KB,Lalgudi PV,Brignole EJ,Gu X,Saxton RA,Chantranupong L,Kolibius J,Quast JP,Sabatini DM

Fri Jul 01 00:00:00 UTC 2022

The SZT2 Interactome Unravels New Functions of the KICSTOR Complex.

Cells

Cattelani C,Lesiak D,Liebscher G,Singer II,Stasyk T,Wallnöfer MH,Heberle AM,Corti C,Hess MW,Pfaller K,Kwiatkowski M,Pramstaller PP,Hicks AA,Thedieck K,Müller T,Huber LA,Eca Guimaraes de Araujo M

Sat Oct 09 00:00:00 UTC 2021

Dihydroxyacetone phosphate signals glucose availability to mTORC1.

Nature metabolism

Orozco JM,Krawczyk PA,Scaria SM,Cangelosi AL,Chan SH,Kunchok T,Lewis CA,Sabatini DM

Tue Sep 01 00:00:00 UTC 2020

Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.

The Journal of biological chemistry

Shen K,Valenstein ML,Gu X,Sabatini DM

Fri Feb 22 00:00:00 UTC 2019

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.

Nature

Shen K,Huang RK,Brignole EJ,Condon KJ,Valenstein ML,Chantranupong L,Bomaliyamu A,Choe A,Hong C,Yu Z,Sabatini DM

Thu Apr 05 00:00:00 UTC 2018

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.

Nature

Shen K,Huang RK,Brignole EJ,Condon KJ,Valenstein ML,Chantranupong L,Bomaliyamu A,Choe A,Hong C,Yu Z,Sabatini DM

Thu Apr 05 00:00:00 UTC 2018

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.

Nature

Wolfson RL,Chantranupong L,Wyant GA,Gu X,Orozco JM,Shen K,Condon KJ,Petri S,Kedir J,Scaria SM,Abu-Remaileh M,Frankel WN,Sabatini DM

Thu Mar 16 00:00:00 UTC 2017

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.

Nature

Wolfson RL,Chantranupong L,Wyant GA,Gu X,Orozco JM,Shen K,Condon KJ,Petri S,Kedir J,Scaria SM,Abu-Remaileh M,Frankel WN,Sabatini DM

Thu Mar 16 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Actin-associated protein 2E4; actin-binding protein; kaptin; kaptin (actin binding protein); KICSTOR complex protein kaptin

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Gene Aliases: 2310042D10Rik; 2E4; C030013F01Rik; KPTN; MRT41

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UniProt ID: (Human) Q9Y664

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Entrez Gene ID: (Human) 11133, (Mouse) 70394, (Rat) 308107

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Function(s)

actin binding molecular_function

Process(es)

movement of cell or subcellular component actin filament organization sensory perception of sound biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KPTN Polyclonal Antibody

KPTN Antibody (16094-1-AP) in ICC/IF

Product Details

16094-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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