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FIGURE: 1 / 1
KSR2 Antibody (H00283455-B01P) in WB
Western Blot analysis of KSR2 expression in transfected 293T cell line (H00283455-T01) by KSR2 MaxPab polyclonal antibody.
Lane 1: KSR2 transfected lysate(91.19 KDa).
Lane 2: Non-transfected lysate.
Lane 1: KSR2 transfected lysate(91.19 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00283455-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KSR2 (NP_775869.2, 1 a.a. approximately 829 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MTDEQVCETV EKYGANREEC ARLNASLSCL RNVHMSGGNL SKQDWTIQWP TTETGKENNP VCPPEPTPWI RTHLSQSPRV PSKCVQHYCH TSPTPGAPVY THVDRLTVDA YPGLCPPPPL ESGHRSLPPS PRQRHAVRTP PRTPNIVTTV TPPGTPPMRK KNKLKPPGTP PPSSRKLIHL IPGFTALHRS KSHEFQLGHR VDEAHTPKAK KKSKPLNLKI HSSVGSCENI PSQQRSPLLS ERSLRSFFVG HAPFLPSTPP VHTEANFSAN TLSVPRWSPQ IPRRDLGNSI KHRFSTKYWM SQTCTVCGKG MLFGLKCKNC KLKCHNKCTK EAPPCHLLII HRGDPARLVR TESVPCDINN PLRKPPRYSD LHISQTLPKT NKINKDHIPV PYQPDSSSNP SSTTSSTPSS PAPPLPPSAT PPSPLHPSPQ CTRQQKNFNL PASHYYKYKQ QFIFPDVVPV PETPTRAPQV ILHPVTSNPI LEGNPLLQIE VEPTSENEEV HDEAEESEDD FEEMNLSLLS ARSFPRKASQ TSIFLQEWDI PFEQLEIGEL IGKGRFGQVY HGRWHGEVAI RLIDIERDNE DQLKAFKREV MAYRQTRHEN VVLFMGACMS PPHLAIITSL CKGRTLYSVV RDAKIVLDVN KTRQIAQEIV KGMGYLHAKG ILHKDLKSKN VFYDNGKVVI TDFGLFSISG VLQAGRREDK LRIQNGWLCH LAPEIIRQLS PDTEEDKLPF SKHSDVFALG TIWYELHARE WPFKTQPAEA IIWQMGTGMK PNLSQIGMGK EISDILLFCW AFEQEERPTF TKLMDMLEKL PKRNRRLSHP GHFWKSAEL
Target Information
KSR2 serine/threonine kinase or kinase suppressor of Ras 2 specifically regulates the activity of MEKK3 and COT but not other members of the MAP3K family. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans. Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hKSR2; Kinase suppressor of Ras 2
Gene Aliases: KSR2
UniProt ID: (Human) Q6VAB6
Entrez Gene ID: (Human) 283455
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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