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KTN1 Polyclonal Antibody

KTN1 Antibody in Immunocytochemistry (ICC/IF)

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KTN1 Antibody (19841-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using KTN1 antibody (Product # 19841-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

KTN1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

KTN1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19841-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KTN1 Fusion Protein Ag13854 (951-1307 aa encoded by BC117132)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody reacts with normal gastrointestinal epithelium as well as gastrointestinal and breast tumors, resulting in a cytoplasmic staining pattern.

Immunogen sequence: KSQIEQLKQ QNYQQASSFP PHEELLKVIS EREKEISGLW NELDSLKDAV EHQRKKNNDL REKNWEAMEA LASTEKMLQD KVNKTSKERQ QQVEAVELEA KEVLKKLFPK VSVPSNLSYG EWLHGFEKKA KECMAGTSGS EEVKVLEHKL KEADEMHTLL QLECEKYKSV LAETEGILQK LQRSVEQEEN KWKVKVDESH KTIKQMQSSF TSSEQELERL RSENKDIENL RREREHLEME LEKAEMERST YVTEVRELKA QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA AGDTTVIENS DVSPETESSE KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK EHYQVLE (951-1307 aa encoded by BC117132)

Target Information

Various cellular organelles and vesicles are transported along the microtubules in the cytoplasm. Likewise, membrane recycling of the endoplasmic reticulum (ER), Golgi assembly at the microtubule organizing center, and alignment of lysosomes along microtubules are all related processes. The transport of organelles requires a special class of microtubule-associated proteins (MAPs). One of these is the molecular motor kinesin an ATPase that moves vesicles unidirectionally toward the plus end of the microtubule. Another such MAP is kinectin, a large integral ER membrane protein. Antibodies directed against kinectin have been shown to inhibit its binding to kinesin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function.

Science (New York, N.Y.)

Jang W,Puchkov D,Samsó P,Liang Y,Nadler-Holly M,Sigrist SJ,Kintscher U,Liu F,Mamchaoui K,Mouly V,Haucke V

Fri Dec 16 00:00:00 UTC 2022

ER proteins decipher the tubulin code to regulate organelle distribution.

Nature

Zheng P,Obara CJ,Szczesna E,Nixon-Abell J,Mahalingan KK,Roll-Mecak A,Lippincott-Schwartz J,Blackstone C

Sat Jan 01 00:00:00 UTC 2022

The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.

Clinical science (London, England : 1979)

Hu X,Xiang L,He D,Zhu R,Fang J,Wang Z,Cao K

Fri Feb 12 00:00:00 UTC 2021

The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.

Clinical science (London, England : 1979)

Hu X,Xiang L,He D,Zhu R,Fang J,Wang Z,Cao K

Fri Feb 12 00:00:00 UTC 2021

CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease.

Science translational medicine

Picó S,Parras A,Santos-Galindo M,Pose-Utrilla J,Castro M,Fraga E,Hernández IH,Elorza A,Anta H,Wang N,Martí-Sánchez L,Belloc E,Garcia-Esparcia P,Garrido JJ,Ferrer I,Macías-García D,Mir P,Artuch R,Pérez B,Hernández F,Navarro P,López-Sendón JL,Iglesias T,Yang XW,Méndez R,Lucas JJ

Wed Sep 29 00:00:00 UTC 2021

Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture.

EMBO reports

Spits M,Heesterbeek IT,Voortman LM,Akkermans JJ,Wijdeven RH,Cabukusta B,Neefjes J

Wed Mar 03 00:00:00 UTC 2021

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy.

Current biology : CB

Chen Q,Xiao Y,Chai P,Zheng P,Teng J,Chen J

Mon Mar 04 00:00:00 UTC 2019

DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.

Cell research

Zheng P,Chen Q,Tian X,Qian N,Chai P,Liu B,Hu J,Blackstone C,Zhu D,Teng J,Chen J

Wed Aug 01 00:00:00 UTC 2018

DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.

Cell research

Zheng P,Chen Q,Tian X,Qian N,Chai P,Liu B,Hu J,Blackstone C,Zhu D,Teng J,Chen J

Wed Aug 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: CG-1 antigen; Kinectin; kinectin 1 (kinesin receptor); Kinesin receptor; ktn1

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Gene Aliases: CG1; KIAA0004; KNT; KTN1; MU-RMS-40.19

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UniProt ID: (Human) Q86UP2, (Mouse) Q61595

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Entrez Gene ID: (Human) 3895, (Mouse) 16709

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Function(s)

protein binding kinesin binding poly(A) RNA binding cadherin binding involved in cell-cell adhesion

Process(es)

microtubule-based movement cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KTN1 Polyclonal Antibody

KTN1 Antibody (19841-1-AP) in ICC/IF

Product Details

19841-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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