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Alomone Labs, LTD
KV1.2 (KCNA2) (extracellular) Polyclonal Antibody
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FIGURE: 1 / 2
KV1.2 (KCNA2) (extracellular) Antibody (APC-162-200UL) in ICC/IF
Expression of KV1.2 in live intact rat PC12 cells - Cell surface detection of KV1.2 in live intact rat PC12 pheochromocytoma cells. A. Extracellular staining of cells with Anti-KV1.2 (KCNA2) (extracellular) Antibody (#APC-162), (1:50), followed by goat Anti-rabbit-AlexaFluor-488 secondary Antibody (green). B. Live view of the cells. C. Merge of A and B.
Product Details
APC-162-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)RDENEDMHGGGVT, corresponding to amino acid residues 189-201 of rat KV1.2, 1st extracellular loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
Kcna2 is a voltage-gated potassium channel (KV) that belongs to the 6-TM family of potassium channel and also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). The Kcna2 gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. Kcna2 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. Further, Kcna2 belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of the Kcna2 gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MK2; Potassium (K+) channel protein alpha 2, voltage dependent; potassium voltage gated channel shaker related subfamily member 2; Potassium voltage-gated channel subfamily A member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; RAK; RBK2; RCK5; RP11-284N8.1; Voltage-gated potassium channel subunit Kv1.2
Gene Aliases: Akr6a4; BK2; ENSMUSG00000074335; Gm10672; Kca1-2; Kcna2; Kv1.2; Mk-2; NGK1
UniProt ID: (Mouse) P63141, (Rat) P63142
Entrez Gene ID: (Mouse) 16490, (Rat) 25468
transport
ion transport
potassium ion transport
regulation of dopamine secretion
neuronal action potential
sensory perception of pain
optic nerve structural organization
regulation of ion transmembrane transport
regulation of circadian sleep/wake cycle, non-REM sleep
protein oligomerization
protein homooligomerization
transmembrane transport
potassium ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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