Alomone Labs, LTD

KV1.5 (KCNA5) (extracellular) Polyclonal Antibody

View all (13) KV1.5 (KCNA5) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

APC-150-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

1:200
-

Flow Cytometry (Flow)

5 µg
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)DERELLRHPPVP(K), corresponding to amino acid residues 268-279 of rat KV1.5, 1st extracellular loop
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

In neurons voltage-dependent potassium channels are key determinants of the resting membrane potential and of membrane excitability, conditioning the frequency, and shape of action potential.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cardiac potassium channel; HPCN1; insulinoma and islet potassium channel; MGC117058; MGC117059; Potassium (K+) channel protein alpha 5; potassium channel 1; potassium channel, voltage gated shaker related subfamily A, member 5; potassium voltage gated channel, shaker related subfamily, member 5; Potassium voltage-gated channel subfamily A member 5; potassium voltage-gated channel, shaker-related subfamily, member 5; RCK7; RK4; Voltage-gated potassium channel HK2; voltage-gated potassium channel protein Kv1.5; Voltage-gated potassium channel subunit Kv1.5

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Gene Aliases: ATFB7; HCK1; HK2; HPCN1; KCNA5; Kv1; KV1.5; PCN1

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UniProt ID: (Human) P22460, (Rat) P19024

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Entrez Gene ID: (Human) 3741, (Rat) 25470

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Function(s)
receptor binding delayed rectifier potassium channel activity protein binding outward rectifier potassium channel activity potassium channel inhibitor activity protein kinase binding alpha-actinin binding voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in SA node cell action potential repolarization scaffold protein binding voltage-gated potassium channel activity
Process(es)
response to hypoxia potassium ion transport response to mechanical stimulus response to organic substance regulation of vasoconstriction regulation of membrane potential response to hydrogen peroxide regulation of potassium ion transport negative regulation of potassium ion transport protein oligomerization protein homooligomerization negative regulation of cytosolic calcium ion concentration potassium ion homeostasis response to hyperoxia membrane hyperpolarization regulation of atrial cardiac muscle cell membrane repolarization potassium ion export potassium ion transmembrane transport atrial cardiac muscle cell action potential regulation of heart rate by cardiac conduction positive regulation of G1/S transition of mitotic cell cycle positive regulation of myoblast proliferation Notch signaling pathway regulation of insulin secretion membrane repolarization during bundle of His cell action potential membrane repolarization during SA node cell action potential
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