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Invitrogen
KV3.2 (KCNC2) Polyclonal Antibody
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KV3.2 (KCNC2) Antibody (PA5-115448) in IHC (P)
Immunohistochemistry analysis of KV3.2 (KCNC2) in human mammary cancer and para-carcinoma tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with KV3.2 (KCNC2) polyclonal antibody (Product # PA5-115448) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-115448
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KCNC2(Accession Q96PR1), corresponding to amino acid residues G180-F230.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900084
Product Specific Information
Antibody detects endogenous levels of total KCNC2.
Target Information
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels. The subunits vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits, which include the KV1, KV2, KV3, KV4 and KV9 proteins, as well as accessory subunits that modify the gating properties of the coexpressed KV subunits. KV3.2 is a multipass membrane protein that regulates the voltage-dependent K+ permeability of excitable membranes. The tail of KV3.2 may be influential in the targeting of the channel to specific subcellular compartments and/or the regulation of channel activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Potassium channel voltage-gated Shaw-related subfamily C member 2; potassium channel, voltage gated Shaw related subfamily C, member 2; potassium voltage gated channel, Shaw-related subfamily, member 2; Potassium voltage-gated channel subfamily C member 2; potassium voltage-gated channel, Shaw-related subfamily, member 2; Shaw-like potassium channel; Voltage-gated potassium channel KCNC2; Voltage-gated potassium channel Kv3.2; Voltage-gated potassium channel subunit Kv3.2
Gene Aliases: AW047325; B230117I07; KCNC2; KShIIIA; KV3.2
UniProt ID: (Human) Q96PR1, (Rat) P22462, (Mouse) Q14B80
Entrez Gene ID: (Human) 3747, (Rat) 246153, (Mouse) 268345
response to light intensity
response to organic cyclic compound
response to amine
globus pallidus development
response to magnesium ion
nitric oxide-cGMP-mediated signaling pathway
response to ethanol
regulation of insulin secretion
protein homooligomerization
protein heterooligomerization
cellular response to ammonium ion
cellular response to nitric oxide
potassium ion transmembrane transport
cellular response to toxic substance
positive regulation of potassium ion transmembrane transport
response to nerve growth factor
action potential
response to toxic substance
ion transmembrane transport
transport
ion transport
potassium ion transport
regulation of ion transmembrane transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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