Product References
Epigenetic upregulation of MNAT1 by SMYD2 is linked to PI3K/AKT activation and tumorigenesis of pancreatic adenocarcinoma.
Histology and histopathology
Xu Z,Liu Y,Pan Z,Qin L
PA5-19462 was used in Immunohistochemistry (Paraffin) to investigate the roles of SMYD2 and its interacted molecules in pancreatic adenocarcinoma (PAAD).
Thu Feb 01 00:00:00 UTC 2024
Effect of Oleoylethanolamide-Based Dietary Supplement on Systemic Inflammation in the Development of Alimentary-Induced Obesity in Mice.
Nutrients
Ivashkevich D,Ponomarenko A,Manzhulo I,Sultanov R,Dyuizen I
PA5-19462 was used in Immunohistochemistry to indicate the complex action of OEA-DS in obesity, which includes a reduction of systemic inflammation.
Thu Oct 12 00:00:00 UTC 2023
Mirabegron displays anticancer effects by globally browning adipose tissues.
Nature communications
Sun X,Sui W,Mu Z,Xie S,Deng J,Li S,Seki T,Wu J,Jing X,He X,Wang Y,Li X,Yang Y,Huang P,Ge M,Cao Y
PA5-19462 was used in Immunohistochemistry to demonstrate that mirabegron represents a paradigm of anticancer drugs with a distinct mechanism for the effective treatment of multiple cancers.
Wed Nov 22 00:00:00 UTC 2023
Reversion of breast epithelial polarity alterations caused by obesity.
NPJ breast cancer
Holmes J,Gaber M,Jenks MZ,Wilson A,Loy T,Lepetit C,Vitolins MZ,Herbert BS,Cook KL,Vidi PA
PA5-19462 was used in Immunohistochemistry to show that obesity and/or dietary factors modulate tissue markers of risk.
Tue May 09 00:00:00 UTC 2023
miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication.
Cell death & disease
Fuertes T,Álvarez-Corrales E,Gómez-Escolar C,Ubieto-Capella P,Serrano-Navarro Á,de Molina A,Méndez J,Ramiro AR,de Yébenes VG
PA5-19462 was used in Immunohistochemistry to provide evidence for the effectiveness of a new miRNA-based ibrutinib combination therapy for DLBCL and unveil the miR-28-plus-ibrutinib gene signature as a new predictor of outcome in ABC-DLBCL patients.
Wed Oct 18 00:00:00 UTC 2023
Antibody gene transfer treatment drastically improves epidermal pathology in a keratitis ichthyosis deafness syndrome model using male mice.
EBioMedicine
Peres C,Sellitto C,Nardin C,Putti S,Orsini T,Di Pietro C,Marazziti D,Vitiello A,Calistri A,Rigamonti M,Scavizzi F,Raspa M,Zonta F,Yang G,White TW,Mammano F
PA5-19462 was used in Immunohistochemistry to show that AAVmAb treatment eliminated abnormal keratinocyte proliferation and enlarged cell size, decreased apoptosis, and restored the normal distribution of keratin expression.
Wed Mar 01 00:00:00 UTC 2023
Postnatal intestinal mucosa and gut microbial composition develop hand in hand: A mouse study.
Biomedical journal
Pandey U,Aich P
PA5-19462 was used in Immunohistochemistry to reveal the importance and interplay of host factors and the microbiome in gut development and intestinal mucosal homeostasis.
Sat Apr 01 00:00:00 UTC 2023
Breast Cancer Brain Metastases: Implementation and Characterization of a Mouse Model Relying on Malignant Cells Inoculation in the Carotid Artery.
Cells
Godinho-Pereira J,Vaz D,Figueira I,Aniceto-Romão J,Krizbai I,Malhó R,Rocha J,Carvalheiro MC,Simões S,Gaspar MM,Brito MA
PA5-19462 was used in Immunohistochemistry to describe an improved procedure, highlighting the tricks and challenges of the process, and providing a characterization of the brain and peripheral metastatic pattern at the cellular and molecular level.
Wed Aug 16 00:00:00 UTC 2023
Modulation of Methacrylated Hyaluronic Acid Hydrogels Enables Their Use as 3D Cultured Model.
Gels (Basel, Switzerland)
Ursini O,Grieco M,Sappino C,Capodilupo AL,Giannitelli SM,Mauri E,Bucciarelli A,Coricciati C,de Turris V,Gigli G,Moroni L,Cortese B
PA5-19462 was used in Immunocytochemistry to provide evidence of cell-matrix interactions that promoted cell budding from the spheroids and the invasiveness in the surrounding environment.
Thu Oct 05 00:00:00 UTC 2023
Maturation and Function of the Intercalated Disc: Report of Two Pediatric Cases Focusing on Cardiac Development and Myocardial Hyperplasia.
Journal of cardiovascular development and disease
van Ham WB,Meijboom EEM,Ligtermoet ML,Nikkels PGJ,van Veen TAB
PA5-19462 was used in Immunohistochemistry-immunofluorescence to describe two sudden death cases of young and apparently healthy-born individuals without external abnormalities compared to an age-matched control.
Sat Aug 19 00:00:00 UTC 2023
CDK4/6 and autophagy inhibitors synergize to suppress the growth of human head and neck squamous cell carcinomas.
Molecular carcinogenesis
Duah E,Seligson ND,Persaud AK,Dam Q,Pabla N,Rocco JW,Li J,Poi M
PA5-19462 was used in Immunohistochemistry to reveal a potential therapeutic strategy that supports the rationale for further clinical development of a combination of CDK4/6 and autophagy inhibitors in HNSCC.
Tue Aug 01 00:00:00 UTC 2023
Brown-fat-mediated tumour suppression by cold-altered global metabolism.
Nature
Seki T,Yang Y,Sun X,Lim S,Xie S,Guo Z,Xiong W,Kuroda M,Sakaue H,Hosaka K,Jing X,Yoshihara M,Qu L,Li X,Chen Y,Cao Y
PA5-19462 was used in Immunohistochemistry to suggest that that cold exposure and activation of BAT through any other approach, such as drugs and devices either alone or in combination with other anticancer therapeutics, will provide a general approach for the effective treatment of various cancers.
Mon Aug 01 00:00:00 UTC 2022
An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea.
Development (Cambridge, England)
Yin W,Liontos A,Koepke J,Ghoul M,Mazzocchi L,Liu X,Lu C,Wu H,Fysikopoulos A,Sountoulidis A,Seeger W,Ruppert C,Günther A,Stainier DYR,Samakovlis C
PA5-19462 was used in Immunocytochemistry to investigate the effects of hedgehog signalling on epithelial tracheal cells.
Tue Feb 01 00:00:00 UTC 2022
An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea.
Development (Cambridge, England)
Yin W,Liontos A,Koepke J,Ghoul M,Mazzocchi L,Liu X,Lu C,Wu H,Fysikopoulos A,Sountoulidis A,Seeger W,Ruppert C,Günther A,Stainier DYR,Samakovlis C
PA5-19462 was used in Immunocytochemistry to investigate the effects of hedgehog signalling on epithelial tracheal cells.
Tue Feb 01 00:00:00 UTC 2022
An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea.
Development (Cambridge, England)
Yin W,Liontos A,Koepke J,Ghoul M,Mazzocchi L,Liu X,Lu C,Wu H,Fysikopoulos A,Sountoulidis A,Seeger W,Ruppert C,Günther A,Stainier DYR,Samakovlis C
PA5-19462 was used in Immunocytochemistry to investigate the effects of hedgehog signalling on epithelial tracheal cells.
Tue Feb 01 00:00:00 UTC 2022
NDRG2 inhibits pyruvate carboxylase-mediated anaplerosis and combines with glutamine blockade to inhibit the proliferation of glioma cells.
American journal of cancer research
Wang J,Sun X,Wang J,Zhang K,Yuan Y,Guo Y,Yao L,Li X,Shen L
PA5-19462 was used in Immunohistochemistry to provide a theoretical and experimental basis for targeting anaplerosis in glioma therapy.
Tue Sep 20 00:00:00 UTC 2022
Suppression of MIR31HG affects the functional properties of thyroid cancer cells depending on the miR-761/MAPK1 axis.
BMC endocrine disorders
Peng S,Chen L,Yuan Z,Duan S
PA5-19462 was used in Immunohistochemistry to demonstrate that MIR31HG targets miR-761 to regulate the functional behaviors of thyroid cancer cells by upregulating MAPK1, highlighting a strong rationale for developing MIR31HG as a novel therapeutic target against thyroid cancer.
Wed Apr 20 00:00:00 UTC 2022
Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction.
EBioMedicine
Lan C,Chen C,Qu S,Cao N,Luo H,Yu C,Wang N,Xue Y,Xia X,Fan C,Ren H,Yang Y,Jose PA,Xu Z,Wu G,Zeng C
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to reveal a significant role of DYRK1A in cardiac repair and suggest a drug target with translational potential for treating cardiomyopathy.
Mon Aug 01 00:00:00 UTC 2022
Diffusion-Weighted MRI as Non-Invasive Diagnostic Tool for Rectal Cancer Aggressiveness and Correlation with KI-67 Expression in Tumor Tissue.
Asian Pacific journal of cancer prevention : APJCP
El Sayed FM,Nassef EM,Abdelmageed NA,Abdel Maqsoud RR,Abosaif AI
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to assess the relation between apparent diffusion coefficient value and Ki-67 expression index and other pathological parameters in Egyptian rectal carcinoma patients.
Sat Oct 01 00:00:00 UTC 2022
Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.
Science advances
Sanz-Ros J,Romero-García N,Mas-Bargues C,Monleón D,Gordevicius J,Brooke RT,Dromant M,Díaz A,Derevyanko A,Guío-Carrión A,Román-Domínguez A,Inglés M,Blasco MA,Horvath S,Viña J,Borrás C
PA5-19462 was used in Immunohistochemistry to propose that young sEV treatment can promote healthy aging.
Fri Oct 21 00:00:00 UTC 2022
DNA Damage Increases Secreted Aβ40 and Aβ42 in Neuronal Progenitor Cells: Relevance to Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Welty S,Thathiah A,Levine AS
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to provide evidence that in our model, DNA damage is associated with an increase in Aß secretion in neuronal progenitors, which may contribute to the early stages of neuronal pathology in AD.
Thu Jul 07 00:00:00 UTC 2022
COVID-19 instigates adipose browning and atrophy through VEGF in small mammals.
Nature metabolism
Jing X,Wu J,Dong C,Gao J,Seki T,Kim C,Urgard E,Hosaka K,Yang Y,Long S,Huang P,Zheng J,Szekely L,Zhang Y,Tao W,Coquet J,Ge M,Chen Y,Adner M,Cao Y
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to study the mechanistic and functional links between SARS-CoV-2 infection and adipose thermogenesis.
Thu Dec 01 00:00:00 UTC 2022
3D Culture Modeling of Metastatic Breast Cancer Cells in Additive Manufactured Scaffolds.
ACS applied materials & interfaces
Nanou A,Lorenzo-Moldero I,Gazouleas KD,Cortese B,Moroni L
PA5-19462 was used in Western Blot to suggest that static seeding was the optimal seeding method with porosity-dependent efficiency.
Wed Jun 22 00:00:00 UTC 2022
Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Science advances
Poh AR,Love CG,Chisanga D,Steer JH,Baloyan D,Chopin M,Nutt S,Rautela J,Huntington ND,Etemadi N,O'Brien M,O'Keefe R,Ellies LG,Macri C,Mintern JD,Whitehead L,Gangadhara G,Boon L,Chand AL,Lowell CA,Shi W,Pixley FJ,Ernst M
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to suggest that therapeutic targeting of HCK activity enhances response to immunotherapy by simultaneously stimulating immune cell activation and inhibiting the immunosuppressive tumor microenvironment.
Fri Jun 24 00:00:00 UTC 2022
Alterations in hippocampal neurogenesis and hippocampal insulin signaling pathway in rat with metabolic syndrome.
Iranian journal of basic medical sciences
Bayram P,Billur D,Kizil S,Caliskan H,Can B
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to conclude that that the insulin signaling pathway may have an effect on the decreased neurogenesis in the MetS group.
Tue Nov 01 00:00:00 UTC 2022
Berberine increases stromal production of Wnt molecules and activates Lgr5+ stem cells to promote epithelial restitution in experimental colitis.
BMC biology
Luo Z,Li Z,Liang Z,Wang L,He G,Wang D,Shen L,Wang Z,Ma X,Geng F,Wang H,Liu W,Liu H,Li B
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to suggest that berberine acts on the resident stromal cells and ISCs to promote epithelial repair in experimental colitis and that Wnt-ß-Catenin signaling may be a potential target for colitis treatment.
Sat Dec 17 00:00:00 UTC 2022
Medical Grade Honey as a Promising Treatment to Improve Ovarian Tissue Transplantation.
Bioengineering (Basel, Switzerland)
Azevedo AR,Pais AS,Almeida-Santos T,Pires VMR,Pessa P,Marques CC,Nolasco S,Castelo-Branco P,Prates JAM,Lopes-da-Costa L,Laranjo M,Botelho MF,Pereira RMLN,Pimenta JMBGA
PA5-19462 was used in Immunohistochemistry to show that MGH should be considered as a potentially effective and less expensive strategy to improve ovarian tissue transplantation.
Sat Jul 30 00:00:00 UTC 2022
Hsa_circ_0074032 promotes prostate cancer progression through elevating homeobox A1 expression by serving as a microRNA-198 decoy.
Andrologia
Feng C,Wang Q,Deng L,Peng N,Yang M,Wang X
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to demonstrate that high circ_0074032 level in PCa is associated with worse PCa-related prognosis. Circ_0074032 induced cell apoptosis, curbed cell proliferation, migration and invasion in PCa cells and was identified as miR-198 decoy. Circ_0074032 regulates HOXA1 expression and promotes PCa progression via elevating HOXA1 expression through acting as a miR-198 sponge.
Tue Feb 01 00:00:00 UTC 2022
Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation.
Cell research
Wang X,Hu X,Song W,Xu H,Xiao Z,Huang R,Bai Q,Zhang F,Chen Y,Liu Y,Fang J,Li X,Shen Q,Zhao H,Yang X
PA5-19462 was used in Immunocytochemistry to propose that this human-specific protein-lncRNA axis renders an additional yet critical layer of regulation with high physiological relevance in both cancerous and normal developmental processes that require hyperactive nucleoli.
Tue Jun 01 00:00:00 UTC 2021
Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation.
Cell research
Wang X,Hu X,Song W,Xu H,Xiao Z,Huang R,Bai Q,Zhang F,Chen Y,Liu Y,Fang J,Li X,Shen Q,Zhao H,Yang X
PA5-19462 was used in Immunocytochemistry to propose that this human-specific protein-lncRNA axis renders an additional yet critical layer of regulation with high physiological relevance in both cancerous and normal developmental processes that require hyperactive nucleoli.
Tue Jun 01 00:00:00 UTC 2021
miR-17-3p promotes the proliferation of multiple myeloma cells by downregulating P21 expression through LMLN inhibition.
International journal of cancer
Xiang P,Yeung YT,Wang J,Wu Q,Du R,Huang C,Jia X,Gao Y,Zhi Y,Guo F,Wei H,Zhang D,Liu Y,Liu L,Liang L,Wang J,Song Y,Liu K,Fang B
PA5-19462 was used in Immunohistochemistry to evaluate the expression profiles of miR-17-3p in plasma and bone marrow mononuclear cells of monoclonal gammopathy of undetermined significance and multiple myeloma patients and healthy subjects.
Tue Jun 15 00:00:00 UTC 2021
Psychosocial Stress and Age Influence Depression and Anxiety-Related Behavior, Drive Tumor Inflammatory Cytokines and Accelerate Prostate Cancer Growth in Mice.
Frontiers in oncology
Bellinger DL,Dulcich MS,Molinaro C,Gifford P,Lorton D,Gridley DS,Hartman RE
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to characterize the effects of age and isolation combined with restraint (2 h/day) for 14 days post-tumor inoculation on behavior, tumor growth and host defense in the immunocompetent, orthotopic RM-9 murine PCa model.
Tue Oct 05 00:00:00 UTC 2021
Psychosocial Stress and Age Influence Depression and Anxiety-Related Behavior, Drive Tumor Inflammatory Cytokines and Accelerate Prostate Cancer Growth in Mice.
Frontiers in oncology
Bellinger DL,Dulcich MS,Molinaro C,Gifford P,Lorton D,Gridley DS,Hartman RE
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to characterize the effects of age and isolation combined with restraint (2 h/day) for 14 days post-tumor inoculation on behavior, tumor growth and host defense in the immunocompetent, orthotopic RM-9 murine PCa model.
Tue Oct 05 00:00:00 UTC 2021
Translation of Tudor-SN, a novel terminal oligo-pyrimidine (TOP) mRNA, is regulated by the mTORC1 pathway in cardiomyocytes.
RNA biology
Gan S,Su C,Ma J,Liu M,Cui X,Xin L,Ren Y,Gao X,Ge L,Wei M,Yang J
PA5-19462 was used in Immunocytochemistry to suggest that the translational efficiency of Tudor-SN is regulated by the mTORC1 pathway in myocardia and that Tudor-SN is involved in mTORC1-mediated regulation of cardiomyocytic proliferation and cardiac development.
Tue Jun 01 00:00:00 UTC 2021
LncRNA MNX1-AS1 Contributes to Laryngeal Squamous Cell Carcinoma Growth and Migration by Regulating mir-744-5p/bcl9/β-Catenin Axis.
Cell transplantation
Ma B,Ren G,Xu J,Yin C,Shi Y
PA5-19462 was used in Immunohistochemistry to disclose the role of MNX1-AS1 in LSCC progression, and explore whether MNX1-AS1 participates in LSCC progression via targeting miR-744-5p to active BCL9/β-catenin signaling.
Wed Nov 17 00:00:00 UTC 2021
LncRNA MNX1-AS1 Contributes to Laryngeal Squamous Cell Carcinoma Growth and Migration by Regulating mir-744-5p/bcl9/β-Catenin Axis.
Cell transplantation
Ma B,Ren G,Xu J,Yin C,Shi Y
PA5-19462 was used in Immunohistochemistry to disclose the role of MNX1-AS1 in LSCC progression, and explore whether MNX1-AS1 participates in LSCC progression via targeting miR-744-5p to active BCL9/β-catenin signaling.
Wed Nov 17 00:00:00 UTC 2021
Bioengineered Skeletal Muscle as a Model of Muscle Aging and Regeneration.
Tissue engineering. Part A
Rajabian N,Shahini A,Asmani M,Vydiam K,Choudhury D,Nguyen T,Ikhapoh I,Zhao R,Lei P,Andreadis ST
PA5-19462 was used in Immunohistochemistry to suggest that three-dimensional constructs enable organization of contractile units including myosin and actin filaments, thereby providing a powerful platform for the quantitative assessment of muscle myotubes in response to injury, genetic or metabolic disorders, or pharmacological testing.
Fri Jan 01 00:00:00 UTC 2021
Simultaneous detection of multiple mRNAs and proteins in bovine IVD cells and tissue with single cell resolution.
Biotechnology letters
Li K,Varden L,Henderson A,Lufkin T,Kraus P
PA5-19462 was used in Immunohistochemistry to develop a simple, sequential protocol combining RNA is situ hybridisation (RISH) and (IHC) for the simultaneous analysis of multiple transcripts alongside proteins.
Fri Jan 01 00:00:00 UTC 2021
The challenge of ovarian tissue culture: 2D versus 3D culture.
Journal of ovarian research
Pais AS,Reis S,Laranjo M,Caramelo F,Silva F,Botelho MF,Almeida-Santos T
PA5-19462 was used in Immunohistochemistry to compare a conventional (2D) culture with an alginate matrix three-dimensional (3D) model for ovarian tissue culture.
Mon Nov 01 00:00:00 UTC 2021
The challenge of ovarian tissue culture: 2D versus 3D culture.
Journal of ovarian research
Pais AS,Reis S,Laranjo M,Caramelo F,Silva F,Botelho MF,Almeida-Santos T
PA5-19462 was used in Immunohistochemistry to compare a conventional (2D) culture with an alginate matrix three-dimensional (3D) model for ovarian tissue culture.
Mon Nov 01 00:00:00 UTC 2021
KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1.
Molecular cancer
Liu L,Cui J,Zhao Y,Liu X,Chen L,Xia Y,Wang Y,Chen S,Sun S,Shi B,Zou Y
PA5-19462 was used in Immunohistochemistry to establish the critical role of the FOXA1-KDM6A-ARHGDIB axis in restraining the malignancy of BCa and identify KDM6A and EZH2 as potential therapeutic targets in the management of BCa.
Tue May 18 00:00:00 UTC 2021
KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1.
Molecular cancer
Liu L,Cui J,Zhao Y,Liu X,Chen L,Xia Y,Wang Y,Chen S,Sun S,Shi B,Zou Y
PA5-19462 was used in Immunohistochemistry to establish the critical role of the FOXA1-KDM6A-ARHGDIB axis in restraining the malignancy of BCa and identify KDM6A and EZH2 as potential therapeutic targets in the management of BCa.
Tue May 18 00:00:00 UTC 2021
Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America
Amen AM,Fellmann C,Soczek KM,Ren SM,Lew RJ,Knott GJ,Park JE,McKinney AM,Mancini A,Doudna JA,Costello JF
PA5-19462 was used in Immunohistochemistry (Frozen) to provide insights into the mechanism of cancer-specific TERT regulation, uncover rapid effects of GABPB1L-mediated TERT suppression in GBM maintenance, and establish GABPB1L inhibition in combination with chemotherapy as a therapeutic strategy for TERT promoter mutant GBM.
Tue Mar 30 00:00:00 UTC 2021
Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America
Amen AM,Fellmann C,Soczek KM,Ren SM,Lew RJ,Knott GJ,Park JE,McKinney AM,Mancini A,Doudna JA,Costello JF
PA5-19462 was used in Immunohistochemistry (Frozen) to provide insights into the mechanism of cancer-specific TERT regulation, uncover rapid effects of GABPB1L-mediated TERT suppression in GBM maintenance, and establish GABPB1L inhibition in combination with chemotherapy as a therapeutic strategy for TERT promoter mutant GBM.
Tue Mar 30 00:00:00 UTC 2021
Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America
Amen AM,Fellmann C,Soczek KM,Ren SM,Lew RJ,Knott GJ,Park JE,McKinney AM,Mancini A,Doudna JA,Costello JF
PA5-19462 was used in Immunohistochemistry (Frozen) to provide insights into the mechanism of cancer-specific TERT regulation, uncover rapid effects of GABPB1L-mediated TERT suppression in GBM maintenance, and establish GABPB1L inhibition in combination with chemotherapy as a therapeutic strategy for TERT promoter mutant GBM.
Tue Mar 30 00:00:00 UTC 2021
Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid.
eLife
Yu Q,Biswas S,Ma G,Zhao P,Li B,Li J
PA5-19462 was used in Immunohistochemistry to uncover the major mechanisms governing corneal maintenance, regeneration, and aging and identifies the NF-κB-retinoic acid pathway as a therapeutic target for corneal disorders.
Fri Jun 04 00:00:00 UTC 2021
Myocyte Enhancer Factor 2C as a New Player in Human Breast Cancer Brain Metastases.
Cells
Galego S,Kauppila LA,Malhó R,Pimentel J,Brito MA
PA5-19462 was used in Immunohistochemistry to ascertain MEF2C expression in human BCBM, establish the relationship with disease severity, disclose the involvement of vascular endothelial growth factor receptor-2 (VEGFR-2) and β-catenin, also known as KDR and CTNNB1, respectively, and investigate if matched primary tumors express the protein.
Fri Feb 12 00:00:00 UTC 2021
Dynamic Regulation of GH-IGF1 Signaling in Injury and Recovery in Hyperoxia-Induced Neonatal Lung Injury.
Cells
Vohlen C,Mohr J,Fomenko A,Kuiper-Makris C,Grzembke T,Aydogmus R,Wilke R,Hirani D,Dötsch J,Alejandre Alcazar MA
PA5-19462 was used in Immunohistochemistry to investigate the growth hormone (GH-) and IGF1 signaling (1) in newborn mice with acute and prolonged exposure to hyperoxia as well as after recovery in room air; and (2) in cultured murine lung epithelial cells (MLE-12) and primary neonatal lung fibroblasts (pLFs) after treatment with GH, IGF1, and IGF1-receptor (IGF1-R) inhibitor or silencing of GH-receptor (Ghr) and Igf1r using the siRNA technique.
Fri Oct 29 00:00:00 UTC 2021
Effects of FSH treatment and withdrawal during proestrus on uterine proliferation and steroid hormone receptor expression in beef heifers.
Animal science journal = Nihon chikusan Gakkaiho
Bunma T,Kanjanaruch C,Kogram N,Uriyapongson S,Khanthusaeng V,Navanukraw C
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to show that FSH administration during proestrus stimulates uterine cell proliferation, and ESR2 expressions are affected by FSH during proestrus and differentially distributed in the uterine regions.
Fri Sep 10 00:00:00 UTC 2021
Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation.
The Journal of clinical investigation
Gong X,Tian M,Cao N,Yang P,Xu Z,Zheng S,Liao Q,Chen C,Zeng C,Jose PA,Wang DZ,Jian Z,Xiao Y,Jiang DS,Wei X,Zhang B,Wang Y,Chen K,Wu G,Zeng C
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to investigate circular RNAs in vascular remodelling.
Wed Dec 15 00:00:00 UTC 2021
Human Mesenchymal Stromal Cell-Derived Exosomes Promote In Vitro Wound Healing by Modulating the Biological Properties of Skin Keratinocytes and Fibroblasts and Stimulating Angiogenesis.
International journal of molecular sciences
Tutuianu R,Rosca AM,Iacomi DM,Simionescu M,Titorencu I
PA5-19462 was used in Immunocytochemistry to test if MSC-derived exosomes could accelerate wound healing by enhancing the biological properties of the main cell types involved in the key phases of this process.
Wed Jun 09 00:00:00 UTC 2021
NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis.
The Journal of cell biology
Huang R,Yuan DJ,Li S,Liang XS,Gao Y,Lan XY,Qin HM,Ma YF,Xu GY,Schachner M,Sytnyk V,Boltze J,Ma QH,Li S
PA5-19462 was used in Immunohistochemistry-immunofluorescence to study the role of NCAM in mediating neural progenitor cell proliferation and fate decision during corticogenesis.
Mon Jan 06 00:00:00 UTC 2020
NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis.
The Journal of cell biology
Huang R,Yuan DJ,Li S,Liang XS,Gao Y,Lan XY,Qin HM,Ma YF,Xu GY,Schachner M,Sytnyk V,Boltze J,Ma QH,Li S
PA5-19462 was used in Immunohistochemistry-immunofluorescence to study the role of NCAM in mediating neural progenitor cell proliferation and fate decision during corticogenesis.
Mon Jan 06 00:00:00 UTC 2020
Maternal arginine supplementation enhances thermogenesis in the newborn lamb.
Journal of animal science
McKnight SM,Simmons RM,Wu G,Satterfield MC
PA5-19462 was used in Immunohistochemistry to determine if maternal arginine supplementation could enhance thermogenesis in the neonate.
Fri May 01 00:00:00 UTC 2020
β3-Adrenoreceptor Blockade Induces Stem Cells Differentiation in Melanoma Microenvironment.
International journal of molecular sciences
Calvani M,Bruno G,Dabraio A,Subbiani A,Bianchini F,Fontani F,Casazza G,Vignoli M,De Logu F,Frenos S,Filippi L,Favre C
Published figure using Ki-67 polyclonal antibody (Product # PA5-19462) in Immunohistochemistry
Thu Feb 20 00:00:00 UTC 2020
Retinoic Acid Is Required for Oligodendrocyte Precursor Cell Production and Differentiation in the Postnatal Mouse Corpus Callosum.
eNeuro
Morrison VE,Smith VN,Huang JK
Published figure using Ki-67 polyclonal antibody (Product # PA5-19462) in Immunofluorescence
Fri May 21 00:00:00 UTC 2021
Plasminogen is a master regulator and a potential drug candidate for the healing of radiation wounds.
Cell death & disease
Fallah M,Viklund E,Bäckman A,Brodén J,Lundskog B,Johansson M,Blomquist M,Wilczynska M,Ny T
Published figure using Ki-67 polyclonal antibody (Product # PA5-19462) in Immunohistochemistry
Mon Mar 23 00:00:00 UTC 2020
Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors.
Nature communications
Hosaka K,Yang Y,Seki T,Du Q,Jing X,He X,Wu J,Zhang Y,Morikawa H,Nakamura M,Scherzer M,Sun X,Xu Y,Cheng T,Li X,Liu X,Li Q,Liu Y,Hong A,Chen Y,Cao Y
PA5-19462 was used in Immunohistochemistry to show that FGF-2 modulates tumor vessels by recruiting NG2+ pricytes onto tumor microvessels through a PDGFRβ-dependent mechanism.
Fri Jul 24 00:00:00 UTC 2020
Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors.
Nature communications
Hosaka K,Yang Y,Seki T,Du Q,Jing X,He X,Wu J,Zhang Y,Morikawa H,Nakamura M,Scherzer M,Sun X,Xu Y,Cheng T,Li X,Liu X,Li Q,Liu Y,Hong A,Chen Y,Cao Y
PA5-19462 was used in Immunohistochemistry to show that FGF-2 modulates tumor vessels by recruiting NG2+ pricytes onto tumor microvessels through a PDGFRβ-dependent mechanism.
Fri Jul 24 00:00:00 UTC 2020
Differential Proliferation and Maturation of Subcortical Astrocytes During Postnatal Development.
Frontiers in neuroscience
Shoneye T,Orrego AT,Jarvis R,Men Y,Chiang MSR,Yang Y
PA5-19462 was used in Immunohistochemistry to investigate proliferation of subcortical, especially hypothalamic, astrocytes during postnatal development using genetic labeling of astrocytes and pulse-chase EdU labeling of proliferating cells.
Thu Nov 21 00:00:00 UTC 2024
Differential Proliferation and Maturation of Subcortical Astrocytes During Postnatal Development.
Frontiers in neuroscience
Shoneye T,Orrego AT,Jarvis R,Men Y,Chiang MSR,Yang Y
PA5-19462 was used in Immunohistochemistry to investigate proliferation of subcortical, especially hypothalamic, astrocytes during postnatal development using genetic labeling of astrocytes and pulse-chase EdU labeling of proliferating cells.
Thu Nov 21 00:00:00 UTC 2024
Osmotic Gradients in Epithelial Acini Increase Mechanical Tension across E-cadherin, Drive Morphogenesis, and Maintain Homeostasis.
Current biology : CB
Narayanan V,Schappell LE,Mayer CR,Duke AA,Armiger TJ,Arsenovic PT,Mohan A,Dahl KN,Gleghorn JP,Conway DE
PA5-19462 was used in Immunocytochemistry to study the cellular biomechanics of acini morphogenesis and homeostasis through MDCK-2 cells.
Mon Feb 24 00:00:00 UTC 2020
RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism.
JCI insight
Senatus L,López-Díez R,Egaña-Gorroño L,Liu J,Hu J,Daffu G,Li Q,Rahman K,Vengrenyuk Y,Barrett TJ,Dewan MZ,Guo L,Fuller D,Finn AV,Virmani R,Li H,Friedman RA,Fisher EA,Ramasamy R,Schmidt AM
PA5-19462 was used in Immunohistochemistry to add a new dimension to the immunometabolic sphere of perturbations that impair regression of established diabetic atherosclerosis.
Thu Jul 09 00:00:00 UTC 2020
Cell-free vascular grafts that grow with the host.
Advanced functional materials
Nasiri B,Row S,Smith RJ,Swartz DD,Andreadis ST
PA5-19462 was used in Immunohistochemistry (Paraffin) to suggest that VEGF-based A-TEVs may be suitable for treatment of congenital heart disorders to alleviate the need for repeated surgeries, which are currently standard practice.
Wed Nov 25 00:00:00 UTC 2020
Angiomatous hyperplasia in the heart of a young rat.
Journal of toxicologic pathology
Piccicuto V,Dincer Z,Walker S,Gray C
PA5-19462 was used in Immunohistochemistry to repost and describe a case where hyperplasia in the heart which is an unusual location in a young male Sprague-Dawley rat in a short-term toxicity study.
Wed Jan 01 00:00:00 UTC 2020
FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway.
International journal of oncology
Lv Q,Wang G,Zhang Y,Han X,Li H,Le W,Zhang M,Ma C,Wang P,Ding Q
PA5-19462 was used in Immunohistochemistry to investigate the function of fatty acid binding protein 5 in clear cell renal cell carcinoma cells.
Mon Apr 01 00:00:00 UTC 2019
Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.
Theranostics
Xian P,Hei Y,Wang R,Wang T,Yang J,Li J,Di Z,Liu Z,Baskys A,Liu W,Wu S,Long Q
Published figure using Ki-67 polyclonal antibody (Product # PA5-19462) in Immunofluorescence
Mon Aug 31 00:00:00 UTC 2020
Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.
Theranostics
Xian P,Hei Y,Wang R,Wang T,Yang J,Li J,Di Z,Liu Z,Baskys A,Liu W,Wu S,Long Q
Published figure using Ki-67 polyclonal antibody (Product # PA5-19462) in Immunofluorescence
Mon Aug 31 00:00:00 UTC 2020
Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice.
International journal of molecular sciences
Mensching L,Djogo N,Keller C,Rading S,Karsak M
PA5-19462 was used in Immunohistochemistry-immunofluorescence to show that cannabinoid receptor 2 might not contribute to basal levels of adult neurogenesis in four-month-old healthy mice.
Thu Aug 01 00:00:00 UTC 2019
Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice.
International journal of molecular sciences
Mensching L,Djogo N,Keller C,Rading S,Karsak M
PA5-19462 was used in Immunohistochemistry-immunofluorescence to show that cannabinoid receptor 2 might not contribute to basal levels of adult neurogenesis in four-month-old healthy mice.
Thu Aug 01 00:00:00 UTC 2019
Transition to the ovulatory season in mares: An investigation of antral follicle receptor gene expression in vivo.
Molecular reproduction and development
Ishak GMA,Dutra GA,Gastal GDA,Gastal MO,Feugang JM,Gastal EL
PA5-19462 was used in Immunohistochemistry-immunofluorescence to offer a great combination for future folliculogenesis studies on mechanisms of follicle selection, development, and ovulation in different species, including women.
Sun Dec 01 00:00:00 UTC 2019
Snake venoms promote stress-induced senescence in human fibroblasts.
Journal of cellular physiology
Lewinska A,Bocian A,Petrilla V,Adamczyk-Grochala J,Szymura K,Hendzel W,Kaleniuk E,Hus KK,Petrillova M,Wnuk M
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate snake-venom-induced adaptive response at a relatively noncytotoxic concentration (0.01 µg/ml) in two human fibroblast cell lines of different origin, namely WI-38 fetal lung fibroblasts and BJ foreskin fibroblasts.
Wed May 01 00:00:00 UTC 2019
Functional peroxisomes are required for β-cell integrity in mice.
Molecular metabolism
Baboota RK,Shinde AB,Lemaire K,Fransen M,Vinckier S,Van Veldhoven PP,Schuit F,Baes M
PA5-19462 was used in Immunohistochemistry to indicate that normal peroxisome metabolism in β-cells is crucial to preserve their structure and function.
Mon Apr 01 00:00:00 UTC 2019
Purpurogallin is a novel mitogen-activated protein kinase kinase 1/2 inhibitor that suppresses esophageal squamous cell carcinoma growth in vitro and in vivo.
Molecular carcinogenesis
Xie X,Zu X,Liu F,Wang T,Wang X,Chen H,Liu K,Wang P,Liu F,Zheng Y,Bode AM,Dong Z,Kim DJ
PA5-19462 was used in Immunocytochemistry, Immunohistochemistry (Paraffin) to indicate that purpurogallin is a novel MEK1/2 inhibitor that could be useful for treating ESCC.
Mon Jul 01 00:00:00 UTC 2019
Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor.
Cell reports
Shen E,Rabe H,Luo L,Wang L,Wang Q,Yin J,Yang X,Liu W,Sido JM,Nakagawa H,Ao L,Kim HJ,Cantor H,Leavenworth JW
PA5-19462 was used in Immunohistochemistry to investigate the mechanisms that maintain Follicular regulatory T lineage identity and suppressive activity.
Tue Nov 12 00:00:00 UTC 2019
Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways.
PloS one
Méndez A,Rojas DA,Ponce CA,Bustamante R,Beltrán CJ,Toledo J,García-Angulo VA,Henriquez M,Vargas SL
PA5-19462 was used in Immunohistochemistry-immunofluorescence to investigate the markers of Clara cell secretion and Notch1 activation in the lungs of immunocompetent rats at 40, 60, and 80 days of age during Pneumocystis primary infection with and without Valproic acid (VPA).
Tue Feb 11 00:00:00 UTC 2020
Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain.
Developmental cell
Dave JM,Mirabella T,Weatherbee SD,Greif DM
Published figure using Ki-67 polyclonal antibody (Product # PA5-19462) in Immunofluorescence
Mon Mar 26 00:00:00 UTC 2018
Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.
Nature communications
Connolly JPR,Slater SL,O'Boyle N,Goldstone RJ,Crepin VF,Ruano-Gallego D,Herzyk P,Smith DGE,Douce GR,Frankel G,Roe AJ
Published figure using Ki-67 polyclonal antibody (Product # PA5-19462) in Immunofluorescence
Wed Oct 10 00:00:00 UTC 2018
Periostin blockade overcomes chemoresistance via restricting the expansion of mesenchymal tumor subpopulations in breast cancer.
Scientific reports
Nakazawa Y,Taniyama Y,Sanada F,Morishita R,Nakamori S,Morimoto K,Yeung KT,Yang J
Published figure using Ki-67 polyclonal antibody (Product # PA5-19462) in Immunofluorescence
Mon Mar 05 00:00:00 UTC 2018
Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization.
EBioMedicine
Yeung YT,Yin S,Lu B,Fan S,Yang R,Bai R,Zhang C,Bode AM,Liu K,Dong Z
Published figure using Ki-67 polyclonal antibody (Product # PA5-19462) in Immunohistochemistry
Thu Feb 01 00:00:00 UTC 2018
Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression.
Redox biology
Lewinska A,Adamczyk-Grochala J,Kwasniewicz E,Deregowska A,Semik E,Zabek T,Wnuk M
PA5-19462 was used in Immunofluorescence to find that DNMT2 may take part in the regulation of cell proliferation and longevity in human fibroblasts and speculate that the manipulation of DNMT2 levels that limits cell proliferation may be potentially useful anticancer strategy.
Sun Apr 01 00:00:00 UTC 2018
Initiation of acute graft-versus-host disease by angiogenesis.
Blood
Riesner K,Shi Y,Jacobi A,Kräter M,Kalupa M,McGearey A,Mertlitz S,Cordes S,Schrezenmeier JF,Mengwasser J,Westphal S,Perez-Hernandez D,Schmitt C,Dittmar G,Guck J,Penack O
PA5-19462 was used in Immunohistochemistry-immunofluorescence to study the role of angiogenesis in the initiation of tissue inflammation during grant versus host disease.
Thu Apr 06 00:00:00 UTC 2017
Multifunctional (3-in-1) cancer theranostics applications of hydroxyquinoline-appended polyfluorene nanoparticles.
Chemical science
Chowdhury SR,Mukherjee S,Das S,Patra CR,Iyer PK
Published figure using Ki-67 polyclonal antibody (Product # PA5-19462) in Immunohistochemistry
Wed Nov 01 00:00:00 UTC 2017
GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Qin J,Sikkema AH,van der Bij K,de Jonge JC,Klappe K,Nies V,Jonker JW,Kok JW,Hoekstra D,Baron W
PA5-19462 was used in Immunohistochemistry to propose that targeted delivery of GD1a to multiple sclerosis lesions may act as a potential novel molecular tool to boost maturation of resident OPCs to overcome remyelination failure and halt disease progression.
Wed Oct 11 00:00:00 UTC 2017
Novel role of NPY in neuroimmune interaction and lung growth after intrauterine growth restriction.
American journal of physiology. Lung cellular and molecular physiology
Thangaratnarajah C,Dinger K,Vohlen C,Klaudt C,Nawabi J,Lopez Garcia E,Kwapiszewska G,Dobner J,Nüsken KD,van Koningsbruggen-Rietschel S,von Hörsten S,Dötsch J,Alejandre Alcázar MA
PA5-19462 was used in Immunohistochemistry to provide new insights in pulmonary neuroimmune interaction, which offer potential strategies to enable lung growth.
Fri Sep 01 00:00:00 UTC 2017
Caspr Controls the Temporal Specification of Neural Progenitor Cells through Notch Signaling in the Developing Mouse Cerebral Cortex.
Cerebral cortex (New York, N.Y. : 1991)
Wu ZQ,Li D,Huang Y,Chen XP,Huang W,Liu CF,Zhao HQ,Xu RX,Cheng M,Schachner M,Ma QH
PA5-19462 was used in immunohistochemistry to report that Caspr regulates the temporal specification of cell fate in radial glial cells of the developing cerebral cortex through Notch signaling
Wed Feb 01 00:00:00 UTC 2017
Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children.
Mutation research. Genetic toxicology and environmental mutagenesis
Vidi PA,Anderson KA,Chen H,Anderson R,Salvador-Moreno N,Mora DC,Poutasse C,Laurienti PJ,Daniel SS,Arcury TA
PA5-19462 was used in Immunohistochemistry-immunofluorescence to anticipate that this monitoring approach of bioavailable pesticides and genotoxicity will enhance our knowledge of the biological effects of pesticides to guide education programs and safety policies.
Sun Oct 01 00:00:00 UTC 2017
Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children.
Mutation research. Genetic toxicology and environmental mutagenesis
Vidi PA,Anderson KA,Chen H,Anderson R,Salvador-Moreno N,Mora DC,Poutasse C,Laurienti PJ,Daniel SS,Arcury TA
PA5-19462 was used in Immunohistochemistry-immunofluorescence to anticipate that this monitoring approach of bioavailable pesticides and genotoxicity will enhance our knowledge of the biological effects of pesticides to guide education programs and safety policies.
Sun Oct 01 00:00:00 UTC 2017
Autonomous and non-autonomous roles for ephrin-B in interneuron migration.
Developmental biology
Talebian A,Britton R,Ammanuel S,Bepari A,Sprouse F,Birnbaum SG,Szabó G,Tamamaki N,Gibson J,Henkemeyer M
PA5-19462 was used in Immunohistochemistry to define both receptor-like and ligand-like roles for the ephrin-B molecules in controlling the migration of interneurons as they populate the neocortex and help establish excitatory/inhibitory (E/I) homeostasis.
Wed Nov 15 00:00:00 UTC 2017
Zika Virus Infects Intermediate Progenitor Cells and Post-mitotic Committed Neurons in Human Fetal Brain Tissues.
Scientific reports
Lin MY,Wang YL,Wu WL,Wolseley V,Tsai MT,Radic V,Thornton ME,Grubbs BH,Chow RH,Huang IC
PA5-19462 was used in Immunohistochemistry-immunofluorescence to study the effect of immune activation after zika virus infection on the pathogenesis of zika virus related microcephaly.
Wed Nov 01 00:00:00 UTC 2017
High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6.
Oncotarget
Chen GL,Luo Y,Eriksson D,Meng X,Qian C,Bäuerle T,Chen XX,Schett G,Bozec A
PA5-19462 was used in immunohistochemistry - paraffin section to study an increasing melanoma cell growth in the bone marrow by a high fat diet that induces osteopontin and interleukin 6
Tue May 03 00:00:00 UTC 2016
Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model.
Scientific reports
Liang Y,Zhu F,Zhang H,Chen D,Zhang X,Gao Q,Li Y
PA5-19462 was used in immunohistochemistry - paraffin section investigate the role of TGF-beta signaling in bladder cancer progression
Tue Jul 05 00:00:00 UTC 2016
AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer.
PloS one
Malanga D,Belmonte S,Colelli F,Scarfò M,De Marco C,Oliveira DM,Mirante T,Camastra C,Gagliardi M,Rizzuto A,Mignogna C,Paciello O,Papparella S,Fagman H,Viglietto G
PA5-19462 was used in immunohistochemistry to study the fact that AKT1E17K is oncogenic in mouse lung and cooperates with carcinogens in creating lung canc er
Mon Jul 18 00:00:00 UTC 2016
Genetic disruption of Smad7 impairs skeletal muscle growth and regeneration.
The Journal of physiology
Cohen TV,Kollias HD,Liu N,Ward CW,Wagner KR
PA5-19462 was used in immunohistochemistry - frozen section to elucidate the role of SMAD7 in muscle
Mon Jun 01 00:00:00 UTC 2015
OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a preclinical F98 rat glioma model.
Journal of magnetic resonance imaging : JMRI
de Souza PC,Balasubramanian K,Njoku C,Smith N,Gillespie DL,Schwager A,Abdullah O,Ritchey JW,Fung KM,Saunders D,Jensen RL,Towner RA
PA5-19462 was used in immunohistochemistry to study the regional effects of OKN-007 in the necrotic core and non-necrotic parenchyma of glioblastoma
Tue Dec 01 00:00:00 UTC 2015
Novel In Vivo model for combinatorial fluorescence labeling in mouse prostate.
The Prostate
Fang X,Gyabaah K,Nickkholgh B,Cline JM,Balaji KC
PA5-19462 was used in immunohistochemistry to discuss animal models of prostate cancer
Mon Jun 15 00:00:00 UTC 2015
Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts.
PloS one
Coutinho de Souza P,Mallory S,Smith N,Saunders D,Li XN,McNall-Knapp RY,Fung KM,Towner RA
PA5-19462 was used in immunohistochemistry to characterize an orthotopic xenograft mouse model and use this model to assess the effects of an anti-cancer agent
Wed May 18 00:00:00 UTC 2016
Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts.
PloS one
Coutinho de Souza P,Mallory S,Smith N,Saunders D,Li XN,McNall-Knapp RY,Fung KM,Towner RA
PA5-19462 was used in immunohistochemistry to characterize an orthotopic xenograft mouse model and use this model to assess the effects of an anti-cancer agent
Wed May 18 00:00:00 UTC 2016
Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.
Scientific reports
Lin CW,Chen YS,Lin CC,Chen YJ,Lo GH,Lee PH,Kuo PL,Dai CY,Huang JF,Chung WL,Yu ML
PA5-19462 was used in immunohistochemistry - paraffin section to determine the role of autophagy in the regulation of liver regeneration after partial hepatectomy
Fri Oct 30 00:00:00 UTC 2015
Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.
Scientific reports
Lin CW,Chen YS,Lin CC,Chen YJ,Lo GH,Lee PH,Kuo PL,Dai CY,Huang JF,Chung WL,Yu ML
PA5-19462 was used in immunohistochemistry - paraffin section to determine the role of autophagy in the regulation of liver regeneration after partial hepatectomy
Fri Oct 30 00:00:00 UTC 2015
Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer.
Oncotarget
Witalison EE,Cui X,Causey CP,Thompson PR,Hofseth LJ
PA5-19462 was used in immunohistochemistry to assess the effects of Chlor-amidine on miR-16
Tue Nov 03 00:00:00 UTC 2015
Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer.
Oncotarget
Witalison EE,Cui X,Causey CP,Thompson PR,Hofseth LJ
PA5-19462 was used in immunohistochemistry to assess the effects of Chlor-amidine on miR-16
Tue Nov 03 00:00:00 UTC 2015
Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.
The Journal of experimental medicine
Liang N,Zhang C,Dill P,Panasyuk G,Pion D,Koka V,Gallazzini M,Olson EN,Lam H,Henske EP,Dong Z,Apte U,Pallet N,Johnson RL,Terzi F,Kwiatkowski DJ,Scoazec JY,Martignoni G,Pende M
PA5-19462 was used in immunohistochemistry - paraffin section to investigate if and how mTOR regulates YAP
Mon Oct 20 00:00:00 UTC 2014
Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissue.
Molecular cancer
Christenson JL,Kane SE
PA5-19462 was used in immunohistochemistry - paraffin section to discuss the contributions of Darpp-32 and t-Darpp to the development of breast cancer.
Fri Aug 15 00:00:00 UTC 2014
Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissue.
Molecular cancer
Christenson JL,Kane SE
PA5-19462 was used in immunohistochemistry - paraffin section to discuss the contributions of Darpp-32 and t-Darpp to the development of breast cancer.
Fri Aug 15 00:00:00 UTC 2014
Development and application of specific cytokine assays in tissue samples from a bottlenose dolphin with hyperinsulinemia.
Frontiers in endocrinology
Eberle KC,Waters TE,Jensen ED,Venn-Watson SK,Sacco RE
PA5-19462 was used in immunohistochemistry - frozen section to characterize a dolphin with insulin resistance and fatty liver disease
Tue Oct 08 00:00:00 UTC 2013
Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Petrik D,Jiang Y,Birnbaum SG,Powell CM,Kim MS,Hsieh J,Eisch AJ
PA5-19462 was used in immunohistochemistry to study the mechanism by which a synthetic small molecule enhances neurogenesis and hippocampal function in adult animals
Wed Aug 01 00:00:00 UTC 2012
β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis.
BMC developmental biology
Mirando AJ,Maruyama T,Fu J,Yu HM,Hsu W
PA5-19462 was used in immunohistochemistry to investigate the role of beta-catenin/cyclin D1 during calvarial morphogenesis
Fri Nov 26 00:00:00 UTC 2010
