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Invitrogen
Kininogen 1 Polyclonal Antibody
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Product Details
PA5-21333
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human HMW Kininogen. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11156188
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-2-thiol proteinase inhibitor; bradykinin; Fitzgerald factor; High molecular weight kininogen; HMWK; Kininogen-1; Williams-Fitzgerald-Flaujeac factor
Gene Aliases: BDK; BK; KNG; KNG1
UniProt ID: (Human) P01042
Entrez Gene ID: (Human) 3827
platelet degranulation
smooth muscle contraction
inflammatory response
negative regulation of cell adhesion
positive regulation of cytosolic calcium ion concentration
blood coagulation, intrinsic pathway
negative regulation of endopeptidase activity
negative regulation of blood coagulation
positive regulation of urine volume
positive regulation of renal sodium excretion
vasodilation
positive regulation of apoptotic process
negative regulation of proteolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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