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NeoBiotechnologies
Ku (p70/p80) (Nuclear Marker) Monoclonal Antibody (KU729), PE
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Product Details
2547-MSM1-PE-100T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
KU729
Immunogen
Nuclear extract of human HL-60 cells
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Does not react with Mouse, Rat or Chicken
Target Information
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II 80 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC75; CTC85; CTCBF; DNA repair protein XRCC5; DNA repair protein XRCC6; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku autoantigen, 80kDa; Ku70; Ku80; Ku86; Ku86 autoantigen related protein 1; Lupus Ku autoantigen protein p70; Lupus Ku autoantigen protein p86; Nuclear factor IV; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 5; X-ray repair cross-complementing protein 6
Gene Aliases: CTC75; CTCBF; G22P1; G22P2; KARP-1; KARP1; KU70; KU80; Ku86; KUB2; ML8; NFIV; TLAA; XRCC5; XRCC6
UniProt ID: (Human) P13010, (Human) P12956
Entrez Gene ID: (Human) 7520, (Human) 2547
DNA binding
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
ATP-dependent DNA helicase activity
protein binding
ATP binding
protein C-terminus binding
ubiquitin protein ligase binding
telomeric DNA binding
transcription regulatory region DNA binding
poly(A) RNA binding
macromolecular complex binding
5'-deoxyribose-5-phosphate lyase activity
telomere maintenance
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
transcription, DNA-templated
cell proliferation
positive regulation of type I interferon production
DNA duplex unwinding
negative regulation of transcription, DNA-templated
regulation of smooth muscle cell proliferation
positive regulation of neurogenesis
hematopoietic stem cell differentiation
cellular response to gamma radiation
cellular response to X-ray
establishment of integrated proviral latency
negative regulation of t-circle formation
DNA ligation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein heterotetramerization
double-strand break repair via classical nonhomologous end joining
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