Invitrogen

Ku70/Ku80 Polyclonal Antibody

View all (5) Ku70/Ku80 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-99488

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human XRCC6(Accession P12956), corresponding to amino acid residues I213-L263.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818421

Product Specific Information

Antibody detects endogenous levels of total Ku70/80.

Target Information

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 5'-dRP/AP lyase Ku70; 70 kDa subunit of Ku antigen; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II 80 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC75; CTC85; CTCBF; DNA repair protein XRCC5; DNA repair protein XRCC6; Ku autoantigen p70 subunit; Ku autoantigen protein p70 homolog; Ku autoantigen protein p86 homolog; Ku autoantigen, 70kDa; Ku autoantigen, 80kD); Ku autoantigen, 80kDa; Ku p70; Ku p80; Ku70; Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa); Ku80; Ku86; Ku86 autoantigen related protein 1; Lupus Ku autoantigen protein p70; Lupus Ku autoantigen protein p86; Nuclear factor IV; thyroid autoantigen; thyroid autoantigen 70 kDa; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross complementation (double-strand-break rejoining; X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD); X-ray repair cross-complementing protein 5; X-ray repair cross-complementing protein 6

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Gene Aliases: 70kDa; AI314015; CTC75; CTCBF; G22P1; G22P2; KARP-1; KARP1; KU70; KU80; Ku86; KUB2; Kup70; Kup80; ML8; NFIV; TLAA; XRCC5; XRCC6

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UniProt ID: (Human) P13010, (Human) P12956, (Mouse) P27641, (Mouse) P23475

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Entrez Gene ID: (Human) 7520, (Human) 2547, (Rat) 363247, (Mouse) 22596, (Rat) 25019, (Mouse) 14375

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Function(s)
DNA binding damaged DNA binding double-stranded DNA binding double-stranded telomeric DNA binding ATP-dependent DNA helicase activity protein binding ATP binding protein C-terminus binding ubiquitin protein ligase binding telomeric DNA binding transcription regulatory region DNA binding poly(A) RNA binding macromolecular complex binding 5'-deoxyribose-5-phosphate lyase activity nucleotide binding helicase activity hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity lyase activity
Process(es)
telomere maintenance double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination transcription, DNA-templated cell proliferation positive regulation of type I interferon production DNA duplex unwinding negative regulation of transcription, DNA-templated regulation of smooth muscle cell proliferation positive regulation of neurogenesis hematopoietic stem cell differentiation cellular response to gamma radiation cellular response to X-ray establishment of integrated proviral latency negative regulation of t-circle formation DNA ligation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterotetramerization double-strand break repair via classical nonhomologous end joining cellular response to DNA damage stimulus brain development response to ionizing radiation V(D)J recombination cellular hyperosmotic salinity response response to drug cellular response to fatty acid DNA repair regulation of transcription, DNA-templated metabolic process
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