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L-Plastin Antibody (600-760) in IHC (P)
Immunohistochemistry: Human Placenta (FFPE) stained with Rabbit anti-L-Plastin antibody (Cat# 600-760) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Product Details
600-760
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the C-terminus of human L-plastin protein
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Positive control: HL60 cells
Cellular location: Cytoplasmic.
Target Information
L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosterones in androgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 65 kDa macrophage protein; bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); DKFZp781A23186; epididymis secretory protein Li 37; FLJ25423; FLJ26114; FLJ39956; L-fimbrin; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); LC64P; LCP-1; Lymphocyte cytosolic protein 1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; plastin 2, L; Plastin-2; pp65
Gene Aliases: AW536232; CP64; D14Ertd310e; HEL-S-37; L-PLASTIN; LC64P; LCP-1; LCP1; LPL; PLS2; pp65
UniProt ID: (Human) P13796, (Mouse) Q61233
Entrez Gene ID: (Human) 3936, (Mouse) 18826, (Rat) 306071
T cell activation involved in immune response
protein kinase A signaling
cell migration
extracellular matrix disassembly
organ regeneration
regulation of intracellular protein transport
wound healing, spreading of cells
actin filament bundle assembly
positive regulation of podosome assembly
response to wounding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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