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Product Details
16616-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LAG-3 Fusion Protein Ag9909 (27-360 aa encoded by BC052589)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AEVPVVWAQ EGAPAQLPCS PTIPLQDLSL LRRAGVTWQH QPDSGPPAAA PGHPLAPGPH PAAPSSWGPR PRRYTVLSVG PGGLRSGRLP LQPRVQLDER GRQRGDFSLW LRPARRADAG EYRAAVHLRD RALSCRLRLR LGQASMTASP PGSLRASDWV ILNCSFSRPD RPASVHWFRN RGQGRVPVRE SPHHHLAESF LFLPQVSPMD SGPWGCILTY RDGFNVSIMY NLTVLGLEPP TPLTVYAGAG SRVGLPCRLP AGVGTRSFLT AKWTPPGGGP DLLVTGDNGD FTLRLEDVSQ AQAGTYTCHI HLQEQQLNAT VTLAIITGQP QVGKE (27-360 aa encoded by B C052589)
Target Information
LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. LAG-3 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation. Surface expression of LAG-3 has been reported on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells usually express LAG-3 at significantly higher levels than CD4+ T cells. Coexpression of LAG-3 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; LAG-3; Lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; sLAG 3; sLAG3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Gene Aliases: CD223; FDC; LAG-3; LAG3; Ly66
UniProt ID: (Human) P18627, (Rat) Q5BK54, (Mouse) Q61790
Entrez Gene ID: (Human) 3902, (Rat) 297596, (Mouse) 16768
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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