Product References
FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer.
Cell death & disease
Wang M,Zhang Z,Chen M,Lv Y,Tian S,Meng F,Zhang Y,Guo X,Chen Y,Yang M,Li J,Qiu T,Xu F,Li Z,Zhang Q,Yang J,Sun J,Zhang H,Zhang H,Li H,Wang W
51-2200 was used in Immunoprecipitation to report the development and characterization of a potent and highly selective small-molecule inhibitor of FUT8, named FDW028, which evidently prolongs the survival of mice with CRC pulmonary metastases (CRPM).
Thu Aug 03 00:00:00 UTC 2023
FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer.
Cell death & disease
Wang M,Zhang Z,Chen M,Lv Y,Tian S,Meng F,Zhang Y,Guo X,Chen Y,Yang M,Li J,Qiu T,Xu F,Li Z,Zhang Q,Yang J,Sun J,Zhang H,Zhang H,Li H,Wang W
51-2200 was used in Immunoprecipitation to report the development and characterization of a potent and highly selective small-molecule inhibitor of FUT8, named FDW028, which evidently prolongs the survival of mice with CRC pulmonary metastases (CRPM).
Thu Aug 03 00:00:00 UTC 2023
FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer.
Cell death & disease
Wang M,Zhang Z,Chen M,Lv Y,Tian S,Meng F,Zhang Y,Guo X,Chen Y,Yang M,Li J,Qiu T,Xu F,Li Z,Zhang Q,Yang J,Sun J,Zhang H,Zhang H,Li H,Wang W
51-2200 was used in Immunoprecipitation to report the development and characterization of a potent and highly selective small-molecule inhibitor of FUT8, named FDW028, which evidently prolongs the survival of mice with CRC pulmonary metastases (CRPM).
Thu Aug 03 00:00:00 UTC 2023
Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathway.
Science advances
Wu J,Han Y,Xu H,Sun H,Wang R,Ren H,Wang G
51-2200 was used in Western Blot to suggest repressive effects of CMA on microglial activation through the p300-associated NF-κB signaling pathway, thus uncovering a mechanistic link between CMA and neuroinflammation.
Fri Oct 06 00:00:00 UTC 2023
Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathway.
Science advances
Wu J,Han Y,Xu H,Sun H,Wang R,Ren H,Wang G
51-2200 was used in Western Blot to suggest repressive effects of CMA on microglial activation through the p300-associated NF-κB signaling pathway, thus uncovering a mechanistic link between CMA and neuroinflammation.
Fri Oct 06 00:00:00 UTC 2023
Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathway.
Science advances
Wu J,Han Y,Xu H,Sun H,Wang R,Ren H,Wang G
51-2200 was used in Western Blot to suggest repressive effects of CMA on microglial activation through the p300-associated NF-κB signaling pathway, thus uncovering a mechanistic link between CMA and neuroinflammation.
Fri Oct 06 00:00:00 UTC 2023
Chaperone mediated autophagy contributes to the newly synthesized histones H3 and H4 quality control.
Nucleic acids research
Hormazabal J,Saavedra F,Espinoza-Arratia C,Martinez NW,Cruces T,Alfaro IE,Loyola A
Published figure using LAMP-2A polyclonal antibody (Product # 51-2200) in Western Blot
Mon Feb 28 00:00:00 UTC 2022
Angiotensin-(1-7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson's disease.
Neural regeneration research
Gao Q,Chen R,Wu L,Huang Q,Wang XX,Tian YY,Zhang YD
51-2200 was used in Immunocytochemistry to conclude that angiotensin-(1-7) reduces α-synuclein aggregation by alleviating autophagy dysfunction in Parkinson's disease.
Sun May 01 00:00:00 UTC 2022
Angiotensin-(1-7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson's disease.
Neural regeneration research
Gao Q,Chen R,Wu L,Huang Q,Wang XX,Tian YY,Zhang YD
51-2200 was used in Immunocytochemistry to conclude that angiotensin-(1-7) reduces α-synuclein aggregation by alleviating autophagy dysfunction in Parkinson's disease.
Sun May 01 00:00:00 UTC 2022
Chaperone-mediated autophagy regulates adipocyte differentiation.
Science advances
Kaushik S,Juste YR,Lindenau K,Dong S,Macho-González A,Santiago-Fernández O,McCabe M,Singh R,Gavathiotis E,Cuervo AM
51-2200 was used in Western Blotting to report here the activation of CMA during adipocyte differentiation and show that CMA regulates adipogenesis at different steps through timely degradation of key regulatory signaling proteins and transcription factors that dictate proliferation, energetic adaptation, and signaling changes required for adipogenesis.
Fri Nov 18 00:00:00 UTC 2022
Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models.
Autophagy
Mavroeidi P,Arvanitaki F,Vetsi M,Becker S,Vlachakis D,Jensen PH,Stefanis L,Xilouri M
51-2200 was used in Immunocytochemistry to reveal that the endogenous oligodendroglial SNCA and TPPP/p25A, the two main GCI components involved in MSA pathogenesis, are degraded via the ALP and that conversely, the presence of pathological SNCA (HsSNCA PFFs) decreases the autophagic flux of OLN cells, albeit without impairing the overall lysosomal activity.
Thu Sep 01 00:00:00 UTC 2022
Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models.
Autophagy
Mavroeidi P,Arvanitaki F,Vetsi M,Becker S,Vlachakis D,Jensen PH,Stefanis L,Xilouri M
51-2200 was used in Immunocytochemistry to reveal that the endogenous oligodendroglial SNCA and TPPP/p25A, the two main GCI components involved in MSA pathogenesis, are degraded via the ALP and that conversely, the presence of pathological SNCA (HsSNCA PFFs) decreases the autophagic flux of OLN cells, albeit without impairing the overall lysosomal activity.
Thu Sep 01 00:00:00 UTC 2022
Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration.
Nature communications
Gomez-Sintes R,Xin Q,Jimenez-Loygorri JI,McCabe M,Diaz A,Garner TP,Cotto-Rios XM,Wu Y,Dong S,Reynolds CA,Patel B,de la Villa P,Macian F,Boya P,Gavathiotis E,Cuervo AM
51-2200 was used in Western Blotting to reveal a mechanism for pharmacological targeting of chaperone-mediated autophagy activation and suggest a therapeutic strategy for retinal degeneration.
Thu Jul 21 00:00:00 UTC 2022
Chaperone-mediated autophagy protects cardiomyocytes against hypoxic-cell death.
American journal of physiology. Cell physiology
Ghosh R,Gillaspie JJ,Campbell KS,Symons JD,Boudina S,Pattison JS
51-2200 was used in Western Blot to establish a protective role for Chaperone-mediated autophagy CMA (via Lamp2a overexpression) against hypoxia-induced cardiomyocyte loss and reveal the intriguing possibility that CMA activation may offer a cardioprotective treatment for ischemic heart disease.
Tue Nov 01 00:00:00 UTC 2022
Chaperone-mediated autophagy sustains haematopoietic stem-cell function.
Nature
Dong S,Wang Q,Kao YR,Diaz A,Tasset I,Kaushik S,Thiruthuvanathan V,Zintiridou A,Nieves E,Dzieciatkowska M,Reisz JA,Gavathiotis E,D'Alessandro A,Will B,Cuervo AM
Published figure using LAMP-2A polyclonal antibody (Product # 51-2200) in Immunocytochemistry
Mon Mar 01 00:00:00 UTC 2021
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Cell
Bourdenx M,Martín-Segura A,Scrivo A,Rodriguez-Navarro JA,Kaushik S,Tasset I,Diaz A,Storm NJ,Xin Q,Juste YR,Stevenson E,Luengo E,Clement CC,Choi SJ,Krogan NJ,Mosharov EV,Santambrogio L,Grueninger F,Collin L,Swaney DL,Sulzer D,Gavathiotis E,Cuervo AM
51-2200 was used in Flow cytometry/Cell sorting to conclude that functional CMA is essential for neuronal proteostasis through the maintenance of a subset of the proteome with a higher risk of misfolding than the general proteome.
Thu May 13 00:00:00 UTC 2021
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
Nature immunology
Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC
51-2200 was used in Western blot to establish NIK as a pivotal regulator of T cell metabolism and highlight a post-translational mechanism of metabolic regulation.
Mon Feb 01 00:00:00 UTC 2021
Sigma-2 receptor antagonists rescue neuronal dysfunction induced by Parkinson's patient brain-derived α-synuclein.
Journal of neuroscience research
Limegrover CS,Yurko R,Izzo NJ,LaBarbera KM,Rehak C,Look G,Rishton G,Safferstein H,Catalano SM
51-2200 was used in Immunocytochemistry to indicate that antagonists of the sigma-2 receptor complex may alleviate α-synuclein oligomer-induced neurotoxicity and are a novel therapeutic approach for disease modification in PD and related α-synucleinopathies.
Thu Apr 01 00:00:00 UTC 2021
Sigma-2 receptor antagonists rescue neuronal dysfunction induced by Parkinson's patient brain-derived α-synuclein.
Journal of neuroscience research
Limegrover CS,Yurko R,Izzo NJ,LaBarbera KM,Rehak C,Look G,Rishton G,Safferstein H,Catalano SM
51-2200 was used in Immunocytochemistry to indicate that antagonists of the sigma-2 receptor complex may alleviate α-synuclein oligomer-induced neurotoxicity and are a novel therapeutic approach for disease modification in PD and related α-synucleinopathies.
Thu Apr 01 00:00:00 UTC 2021
α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia.
Cell adhesion & migration
Desale SE,Chinnathambi S
51-2200 was used in Immunocytochemistry-immunoflourescence to suggest that microglia could be influenced to reduce extracellular Tau seed with dietary fatty acids.
Wed Dec 01 00:00:00 UTC 2021
α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia.
Cell adhesion & migration
Desale SE,Chinnathambi S
51-2200 was used in Immunocytochemistry-immunoflourescence to suggest that microglia could be influenced to reduce extracellular Tau seed with dietary fatty acids.
Wed Dec 01 00:00:00 UTC 2021
α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia.
Cell adhesion & migration
Desale SE,Chinnathambi S
51-2200 was used in Immunocytochemistry-immunoflourescence to suggest that microglia could be influenced to reduce extracellular Tau seed with dietary fatty acids.
Wed Dec 01 00:00:00 UTC 2021
Analysis of lysosomal hydrolase trafficking and activity in human iPSC-derived neuronal models.
STAR protocols
Cuddy LK,Mazzulli JR
51-2200 was used in Immunocytochemistry to analyze the trafficking and activity of lysosomal proteins in patient-derived neurons differentiated from iPSCs.
Fri Mar 19 00:00:00 UTC 2021
Analysis of lysosomal hydrolase trafficking and activity in human iPSC-derived neuronal models.
STAR protocols
Cuddy LK,Mazzulli JR
51-2200 was used in Immunocytochemistry to analyze the trafficking and activity of lysosomal proteins in patient-derived neurons differentiated from iPSCs.
Fri Mar 19 00:00:00 UTC 2021
Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt.
Toxicological sciences : an official journal of the Society of Toxicology
Lenz B,Brink A,Mihatsch MJ,Altmann B,Niederhauser U,Steinhuber B,Wyttenbach N,Fischer H
51-2200 was used in Immunohistochemistry to characterize the invivo-precipitation of RO0728617 and their underlying mechanism(s), and to identify possible screening methods in the drug development process.
Mon Apr 12 00:00:00 UTC 2021
Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt.
Toxicological sciences : an official journal of the Society of Toxicology
Lenz B,Brink A,Mihatsch MJ,Altmann B,Niederhauser U,Steinhuber B,Wyttenbach N,Fischer H
51-2200 was used in Immunohistochemistry to characterize the invivo-precipitation of RO0728617 and their underlying mechanism(s), and to identify possible screening methods in the drug development process.
Mon Apr 12 00:00:00 UTC 2021
Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
Scientific reports
Sweeter JM,Kudrna K,Hunt K,Thomes P,Dickey BF,Brody SL,Dickinson JD
51-2200 was used in Immunocytochemistry to indicate that during peak and resolution phases of MM, autophagy activity rather than secretion is required for elimination of some remaining mucin granules.
Tue Jun 22 00:00:00 UTC 2021
Chaperone-mediated autophagy is involved in the execution of ferroptosis.
Proceedings of the National Academy of Sciences of the United States of America
Wu Z,Geng Y,Lu X,Shi Y,Wu G,Zhang M,Shan B,Pan H,Yuan J
Published figure using LAMP-2A polyclonal antibody (Product # 51-2200) in Western Blot
Tue Feb 19 00:00:00 UTC 2019
Proteome-wide analysis of chaperone-mediated autophagy targeting motifs.
PLoS biology
Kirchner P,Bourdenx M,Madrigal-Matute J,Tiano S,Diaz A,Bartholdy BA,Will B,Cuervo AM
51-2200 was used in Western Blotting to find that KFERQ-like motifs are more frequently located in solvent-exposed regions of proteins, and that the position of acidic and hydrophobic residues in the motif plays the most important role in motif construction.
Wed May 01 00:00:00 UTC 2019
Intracellular Redox-Balance Involvement in Temozolomide Resistance-Related Molecular Mechanisms in Glioblastoma.
Cells
Lo Dico A,Salvatore D,Martelli C,Ronchi D,Diceglie C,Lucignani G,Ottobrini L
Published figure using LAMP-2A polyclonal antibody (Product # 51-2200) in Western Blot
Thu Oct 24 00:00:00 UTC 2019
Analysis of Chaperone-Mediated Autophagy.
Methods in molecular biology (Clifton, N.J.)
Juste YR,Cuervo AM
51-2200 was used in Immunocytochemistry to describe current methodologies to quantitatively analyze CMA activity in different experimental models.
Thu Jun 06 00:00:00 UTC 2019
Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A.
Autophagy
Pajares M,Rojo AI,Arias E,Díaz-Carretero A,Cuervo AM,Cuadrado A
51-2200 was used in Western Blot to determine if nuclear factor, erythroid derived 2, like 2 has an impact on chaperone-mediated autophagy modulation.
Fri Oct 11 00:00:00 UTC 2019
Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A.
Autophagy
Pajares M,Rojo AI,Arias E,Díaz-Carretero A,Cuervo AM,Cuadrado A
51-2200 was used in Western Blot to determine if nuclear factor, erythroid derived 2, like 2 has an impact on chaperone-mediated autophagy modulation.
Fri Oct 11 00:00:00 UTC 2019
Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A.
Autophagy
Pajares M,Rojo AI,Arias E,Díaz-Carretero A,Cuervo AM,Cuadrado A
51-2200 was used in Western Blot to determine if nuclear factor, erythroid derived 2, like 2 has an impact on chaperone-mediated autophagy modulation.
Fri Oct 11 00:00:00 UTC 2019
Imaging Mass Microscopy of Kidneys from Azithromycin-Treated Rats with Phospholipidosis.
The American journal of pathology
Sakurai T,Kamio K,Sasaki K,Nishimoto T,Yamaguchi JI,Sasaki M,Tsutsumi S
51-2200 was used in Immunohistochemistry to reveal the mechanism and identify putative biomarkers of drug-induced phospholipidosis.
Sat Sep 01 00:00:00 UTC 2018
Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes.
Nature communications
Lee SH,Shin SM,Zhong P,Kim HT,Kim DI,Kim JM,Heo WD,Kim DW,Yeo CY,Kim CH,Liu QS
51-2200 was used in Western Blotting and ICC/IF to identify a proximity-dependent, reciprocal mechanism for the regulation of excitatory synapse numbers in local neurons and demonstrate the significance of exosomes in inter-neuronal signalling in the vertebrate brain.
Fri Aug 24 00:00:00 UTC 2018
Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes.
Nature communications
Lee SH,Shin SM,Zhong P,Kim HT,Kim DI,Kim JM,Heo WD,Kim DW,Yeo CY,Kim CH,Liu QS
51-2200 was used in Western Blotting and ICC/IF to identify a proximity-dependent, reciprocal mechanism for the regulation of excitatory synapse numbers in local neurons and demonstrate the significance of exosomes in inter-neuronal signalling in the vertebrate brain.
Fri Aug 24 00:00:00 UTC 2018
Oxidative stress and autophagy-related changes during retinal degeneration and development.
Cell death & disease
Trachsel-Moncho L,Benlloch-Navarro S,Fernández-Carbonell Á,Ramírez-Lamelas DT,Olivar T,Silvestre D,Poch E,Miranda M
51-2200 was used in Western Blotting to identify changes in the levels of oxidative stress and autophagy markers in the murine retina during different phases of retinal development.
Tue Jul 24 00:00:00 UTC 2018
Oxidative stress and autophagy-related changes during retinal degeneration and development.
Cell death & disease
Trachsel-Moncho L,Benlloch-Navarro S,Fernández-Carbonell Á,Ramírez-Lamelas DT,Olivar T,Silvestre D,Poch E,Miranda M
51-2200 was used in Western Blotting to identify changes in the levels of oxidative stress and autophagy markers in the murine retina during different phases of retinal development.
Tue Jul 24 00:00:00 UTC 2018
Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease.
Neurobiology of disease
De Miranda BR,Rocha EM,Bai Q,El Ayadi A,Hinkle D,Burton EA,Timothy Greenamyre J
51-2200 was used in ELISA, Inhibition Assays, Western Blot, Immunohistochemistry to indicate that astrocyte-specific overexpression of hDJ-1 protects neighboring neurons against multiple pathologic features of Parkinson's disease and provides the first direct evidence in vivo of a cell non-autonomous neuroprotective function of astroglial DJ-1.
Sun Jul 01 00:00:00 UTC 2018
Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation.
Autophagy
Gomes LR,Menck CFM,Cuervo AM
51-2200 was used in Western Blotting to demonstrate that chaperone-mediated autophagy mitigates MYC oncogenic activity by promoting its proteasomal degradation.
Thu May 04 00:00:00 UTC 2017
From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.
Toxicological sciences : an official journal of the Society of Toxicology
Braendli-Baiocco A,Festag M,Dumong Erichsen K,Persson R,Mihatsch MJ,Fisker N,Funk J,Mohr S,Constien R,Ploix C,Brady K,Berrera M,Altmann B,Lenz B,Albassam M,Schmitt G,Weiser T,Schuler F,Singer T,Tessier Y
Published figure using LAMP-2A polyclonal antibody (Product # 51-2200) in Immunohistochemistry
Mon May 01 00:00:00 UTC 2017
An Immunohistochemical Investigation of Renal Phospholipidosis and Toxicity in Rats.
International journal of toxicology
Ma JY,Snook S,Garrovillo S,Johnson C,La D
51-2200 was used in Immunohistochemistry to establish the use of LAMP-2 immunohistochemistry as a diagnostic tool and suggest an association between phospholipidosis and the renal tubular injury.
Tue Jun 12 00:00:00 UTC 2018
Databases for technical aspects of immunohistochemistry.
Journal of toxicologic pathology
Furukawa S,Nagaike M,Ozaki K
51-2200 was used in Immunohistochemistry to gather responses to a questionnaire gathering information on suitable choices of antibody for histopathological examination.
Sun Jan 01 00:00:00 UTC 2017
Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88.
Scientific reports
Into T,Horie T,Inomata M,Gohda J,Inoue JI,Murakami Y,Niida S
Fri Apr 21 00:00:00 UTC 2017
Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88.
Scientific reports
Into T,Horie T,Inomata M,Gohda J,Inoue JI,Murakami Y,Niida S
Fri Apr 21 00:00:00 UTC 2017
Regulation of the autophagy system during chronic contractile activity-induced muscle adaptations.
Physiological reports
Kim Y,Hood DA
Published figure using LAMP-2A polyclonal antibody (Product # 51-2200) in Western Blot
Sat Jul 01 00:00:00 UTC 2017
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
The Journal of biological chemistry
Zhang J,Johnson JL,He J,Napolitano G,Ramadass M,Rocca C,Kiosses WB,Bucci C,Xin Q,Gavathiotis E,Cuervo AM,Cherqui S,Catz SD
51-2200 was used in Western Blotting to show that LAMP2A trafficking is regulated by cystinosin, Rab11, and RILP and that CMA up-regulation is a potential clinically relevant mechanism to increase cell survival in cystinosis.
Fri Jun 23 00:00:00 UTC 2017
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
The Journal of biological chemistry
Zhang J,Johnson JL,He J,Napolitano G,Ramadass M,Rocca C,Kiosses WB,Bucci C,Xin Q,Gavathiotis E,Cuervo AM,Cherqui S,Catz SD
51-2200 was used in Western Blotting to show that LAMP2A trafficking is regulated by cystinosin, Rab11, and RILP and that CMA up-regulation is a potential clinically relevant mechanism to increase cell survival in cystinosis.
Fri Jun 23 00:00:00 UTC 2017
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.
Cell metabolism
Mitchell SJ,Madrigal-Matute J,Scheibye-Knudsen M,Fang E,Aon M,González-Reyes JA,Cortassa S,Kaushik S,Gonzalez-Freire M,Patel B,Wahl D,Ali A,Calvo-Rubio M,Burón MI,Guiterrez V,Ward TM,Palacios HH,Cai H,Frederick DW,Hine C,Broeskamp F,Habering L,Dawson J,Beasley TM,Wan J,Ikeno Y,Hubbard G,Becker KG,Zhang Y,Bohr VA,Longo DL,Navas P,Ferrucci L,Sinclair DA,Cohen P,Egan JM,Mitchell JR,Baur JA,Allison DB,Anson RM,Villalba JM,Madeo F,Cuervo AM,Pearson KJ,Ingram DK,Bernier M,de Cabo R
Published figure using LAMP-2A polyclonal antibody (Product # 51-2200) in Western Blot
Tue Jun 14 00:00:00 UTC 2016
Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats.
Autophagy
Xilouri M,Brekk OR,Polissidis A,Chrysanthou-Piterou M,Kloukina I,Stefanis L
51-2200 was used in Western Blotting to highlight the importance of the chaperone-mediated autophagy pathway in the dopaminergic system in rats.
Tue Nov 01 00:00:00 UTC 2016
Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats.
Autophagy
Xilouri M,Brekk OR,Polissidis A,Chrysanthou-Piterou M,Kloukina I,Stefanis L
51-2200 was used in Western Blotting to highlight the importance of the chaperone-mediated autophagy pathway in the dopaminergic system in rats.
Tue Nov 01 00:00:00 UTC 2016
Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats.
Autophagy
Xilouri M,Brekk OR,Polissidis A,Chrysanthou-Piterou M,Kloukina I,Stefanis L
51-2200 was used in Western Blotting to highlight the importance of the chaperone-mediated autophagy pathway in the dopaminergic system in rats.
Tue Nov 01 00:00:00 UTC 2016
AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA.
Autophagy
Kaushik S,Cuervo AM
51-2200 was used in Western Blotting to report that phosphorylation of perilipin (PLIN) 2 is dependent on AMPK and occurs after the interaction of PLIN2 with the chaperone-mediated autophagy chaperone HSPA8/Hsc70.
Tue Dec 13 00:00:00 UTC 2016
Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy?
Aging cell
Basisty N,Dai DF,Gagnidze A,Gitari L,Fredrickson J,Maina Y,Beyer RP,Emond MJ,Hsieh EJ,MacCoss MJ,Martin GM,Rabinovitch PS
51-2200 was used in western blot to research mitochondrial-targeted catalase good for the old mouse proteome but not the young which may function as a reverse antagonistic pleiotropy
Mon Aug 01 00:00:00 UTC 2016
Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.
Journal of Huntington's disease
Vodicka P,Chase K,Iuliano M,Tousley A,Valentine DT,Sapp E,Kegel-Gleason KB,Sena-Esteves M,Aronin N,DiFiglia M
512200 was used in western blot to discuss regulation of mutant huntingtin by transcription factor EB
Sat Oct 01 00:00:00 UTC 2016
Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.
Scientific reports
Shimshek DR,Jacobson LH,Kolly C,Zamurovic N,Balavenkatraman KK,Morawiec L,Kreutzer R,Schelle J,Jucker M,Bertschi B,Theil D,Heier A,Bigot K,Beltz K,Machauer R,Brzak I,Perrot L,Neumann U
51-2200 was used in immunohistochemistry - paraffin section to report that BACE2 and BACE1 inhibition in mice affects melanosome maturation and induces hair depigmentation
Thu Feb 25 00:00:00 UTC 2016
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis.
Nature cell biology
Kaushik S,Cuervo AM
Published figure using LAMP-2A polyclonal antibody (Product # 51-2200) in Western Blot
Mon Jun 01 00:00:00 UTC 2015
Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis.
Cellular and molecular gastroenterology and hepatology
Mareninova OA,Sendler M,Malla SR,Yakubov I,French SW,Tokhtaeva E,Vagin O,Oorschot V,Lüllmann-Rauch R,Blanz J,Dawson D,Klumperman J,Lerch MM,Mayerle J,Gukovsky I,Gukovskaya AS
51-2200 was used in western blot to examine the role of lysosome associated membrane proteins in pancreatitis
Sun Nov 01 00:00:00 UTC 2015
Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis.
Cellular and molecular gastroenterology and hepatology
Mareninova OA,Sendler M,Malla SR,Yakubov I,French SW,Tokhtaeva E,Vagin O,Oorschot V,Lüllmann-Rauch R,Blanz J,Dawson D,Klumperman J,Lerch MM,Mayerle J,Gukovsky I,Gukovskaya AS
51-2200 was used in western blot to examine the role of lysosome associated membrane proteins in pancreatitis
Sun Nov 01 00:00:00 UTC 2015
α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kett LR,Stiller B,Bernath MM,Tasset I,Blesa J,Jackson-Lewis V,Chan RB,Zhou B,Di Paolo G,Przedborski S,Cuervo AM,Dauer WT
51-2200 was used in western blot to investigate how endolysosomal dysfunction causes Parkinson's disease-related neurodegeneration
Wed Apr 08 00:00:00 UTC 2015
α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kett LR,Stiller B,Bernath MM,Tasset I,Blesa J,Jackson-Lewis V,Chan RB,Zhou B,Di Paolo G,Przedborski S,Cuervo AM,Dauer WT
51-2200 was used in western blot to investigate how endolysosomal dysfunction causes Parkinson's disease-related neurodegeneration
Wed Apr 08 00:00:00 UTC 2015
Chaperone-Mediated Autophagy after Traumatic Brain Injury.
Journal of neurotrauma
Park Y,Liu C,Luo T,Dietrich WD,Bramlett H,Hu B
51-2200 was used in western blot to examine how chaperone-mediated autophagy and the ubiquitin-proteasomal system are regulated after traumatic brain injury.
Thu Oct 01 00:00:00 UTC 2015
Chaperone-Mediated Autophagy after Traumatic Brain Injury.
Journal of neurotrauma
Park Y,Liu C,Luo T,Dietrich WD,Bramlett H,Hu B
51-2200 was used in western blot to examine how chaperone-mediated autophagy and the ubiquitin-proteasomal system are regulated after traumatic brain injury.
Thu Oct 01 00:00:00 UTC 2015
Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation.
Nature immunology
Valdor R,Mocholi E,Botbol Y,Guerrero-Ros I,Chandra D,Koga H,Gravekamp C,Cuervo AM,Macian F
Published figure using LAMP-2A polyclonal antibody (Product # 51-2200) in Immunocytochemistry
Sat Nov 01 00:00:00 UTC 2014
Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation.
Nature immunology
Valdor R,Mocholi E,Botbol Y,Guerrero-Ros I,Chandra D,Koga H,Gravekamp C,Cuervo AM,Macian F
Published figure using LAMP-2A polyclonal antibody (Product # 51-2200) in Immunocytochemistry
Sat Nov 01 00:00:00 UTC 2014
High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A.
Cell death and differentiation
Gabandé-Rodríguez E,Boya P,Labrador V,Dotti CG,Ledesma MD
51-2200 was used in Western Blotting to outline a role for sphingomyelin in autophagy modulation and to characterise autophagy abnormalities in Niemann Pick disease type A, for the purpose of therapeutic targeting.
Sun Jun 01 00:00:00 UTC 2014
High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A.
Cell death and differentiation
Gabandé-Rodríguez E,Boya P,Labrador V,Dotti CG,Ledesma MD
51-2200 was used in Western Blotting to outline a role for sphingomyelin in autophagy modulation and to characterise autophagy abnormalities in Niemann Pick disease type A, for the purpose of therapeutic targeting.
Sun Jun 01 00:00:00 UTC 2014
The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release.
Journal of cell science
Escudero CA,Lazo OM,Galleguillos C,Parraguez JI,Lopez-Verrilli MA,Cabeza C,Leon L,Saeed U,Retamal C,Gonzalez A,Marzolo MP,Carter BD,Court FA,Bronfman FC
Thu May 01 00:00:00 UTC 2014
Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction.
The Journal of biological chemistry
Torsvik J,Johansson BB,Dalva M,Marie M,Fjeld K,Johansson S,Bjørkøy G,Saraste J,Njølstad PR,Molven A
51-2200 was used in immunocytochemistry to assess the intracellular distribution of the wild type and mutant carboxyl ester lipase proteins in cellular models
Fri Oct 17 00:00:00 UTC 2014
Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction.
The Journal of biological chemistry
Torsvik J,Johansson BB,Dalva M,Marie M,Fjeld K,Johansson S,Bjørkøy G,Saraste J,Njølstad PR,Molven A
51-2200 was used in immunocytochemistry to assess the intracellular distribution of the wild type and mutant carboxyl ester lipase proteins in cellular models
Fri Oct 17 00:00:00 UTC 2014
Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction.
The Journal of biological chemistry
Torsvik J,Johansson BB,Dalva M,Marie M,Fjeld K,Johansson S,Bjørkøy G,Saraste J,Njølstad PR,Molven A
51-2200 was used in immunocytochemistry to assess the intracellular distribution of the wild type and mutant carboxyl ester lipase proteins in cellular models
Fri Oct 17 00:00:00 UTC 2014
STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy.
Autophagy
Ferreira JV,Fôfo H,Bejarano E,Bento CF,Ramalho JS,Girão H,Pereira P
51-2200 was used in Western Blotting to show that HIF1A can be targeted for degradation in the lysosome by CMA and this targeting is dependent on its interaction with the ubiquitin ligase STUB1.
Sun Sep 01 00:00:00 UTC 2013
PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins.
Neurobiology of aging
Magnaudeix A,Wilson CM,Page G,Bauvy C,Codogno P,Lévêque P,Labrousse F,Corre-Delage M,Yardin C,Terro F
51-2200 was used in western blot to study the effect of protein phosphatase 2A modulation on neuronal autophagy.
Fri Mar 01 00:00:00 UTC 2013
Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration.
Neurobiology of disease
Malkus KA,Ischiropoulos H
51-2200 was used in western blot to investigate why certain parts of the brain are more vulnerable to protein aggregation.
Fri Jun 01 00:00:00 UTC 2012
Amphetamine and methamphetamine reduce striatal dopamine transporter function without concurrent dopamine transporter relocalization.
Journal of neurochemistry
German CL,Hanson GR,Fleckenstein AE
51-2200 was used in western blot to determine dopamine transporter localization following in vivo amphetamine and methamphetamine administration.
Mon Oct 01 00:00:00 UTC 2012
Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease.
Biochimica et biophysica acta
Lai AY,McLaurin J
51-2200 was used in western blot to determine if scyllo-Inositol treatment affects autophagy.
Mon Oct 01 00:00:00 UTC 2012
Muscle degeneration in neuraminidase 1-deficient mice results from infiltration of the muscle fibers by expanded connective tissue.
Biochimica et biophysica acta
Zanoteli E,van de Vlekkert D,Bonten EJ,Hu H,Mann L,Gomero EM,Harris AJ,Ghersi G,d'Azzo A
51-2200 was used in immunohistochemistry - frozen section to assess the skeletal muscle pathology associated with loss of Neu1 function in mice
Tue Aug 10 00:00:00 UTC 2010
Muscle degeneration in neuraminidase 1-deficient mice results from infiltration of the muscle fibers by expanded connective tissue.
Biochimica et biophysica acta
Zanoteli E,van de Vlekkert D,Bonten EJ,Hu H,Mann L,Gomero EM,Harris AJ,Ghersi G,d'Azzo A
51-2200 was used in immunohistochemistry - frozen section to assess the skeletal muscle pathology associated with loss of Neu1 function in mice
Tue Aug 10 00:00:00 UTC 2010
Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies.
The American journal of pathology
Wei J,Fujita M,Nakai M,Waragai M,Sekigawa A,Sugama S,Takenouchi T,Masliah E,Hashimoto M
51-2200 was used in immunocytochemistry and western blot to test if altering endogenous ganglioside levels affects lysosomal pathology in a cellular model of synucleinopathy
Fri May 01 00:00:00 UTC 2009
Entamoeba histolytica uses ferritin as an iron source and internalises this protein by means of clathrin-coated vesicles.
International journal for parasitology
López-Soto F,González-Robles A,Salazar-Villatoro L,León-Sicairos N,Piña-Vázquez C,Salazar EP,de la Garza M
51-2200 was used in immunocytochemistry to test if trophozoites take up ferritin and use it for their growth in axenic culture
Sun Mar 01 00:00:00 UTC 2009
Methods to monitor chaperone-mediated autophagy.
Methods in enzymology
Kaushik S,Cuervo AM
51-2200 was used in Western Blotting to review the experimental approaches used to assess chaperone-mediated autophagy activity in cells in culture and in different organs from animals.
Thu Apr 02 00:00:00 UTC 2009
Methods to monitor chaperone-mediated autophagy.
Methods in enzymology
Kaushik S,Cuervo AM
51-2200 was used in Western Blotting to review the experimental approaches used to assess chaperone-mediated autophagy activity in cells in culture and in different organs from animals.
Thu Apr 02 00:00:00 UTC 2009
Epidermal growth factor receptor translocation to the mitochondria: regulation and effect.
The Journal of biological chemistry
Demory ML,Boerner JL,Davidson R,Faust W,Miyake T,Lee I,Hüttemann M,Douglas R,Haddad G,Parsons SJ
Fri Dec 25 00:00:00 UTC 2009
Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43.
The Journal of biological chemistry
Roscoe W,Veitch GI,Gong XQ,Pellegrino E,Bai D,McLachlan E,Shao Q,Kidder GM,Laird DW
Fri Mar 25 00:00:00 UTC 2005
Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43.
The Journal of biological chemistry
Roscoe W,Veitch GI,Gong XQ,Pellegrino E,Bai D,McLachlan E,Shao Q,Kidder GM,Laird DW
Fri Mar 25 00:00:00 UTC 2005
Ketone bodies stimulate chaperone-mediated autophagy.
The Journal of biological chemistry
Finn PF,Dice JF
Fri Jul 08 00:00:00 UTC 2005
A cycling cis-Golgi protein mediates endosome-to-Golgi traffic.
Molecular biology of the cell
Natarajan R,Linstedt AD
Mon Nov 01 00:00:00 UTC 2004
IkappaB is a substrate for a selective pathway of lysosomal proteolysis.
Molecular biology of the cell
Cuervo AM,Hu W,Lim B,Dice JF
51-2200 was used in Coimmunoprecipitation studies to examine the lysosomal proteolytic pathway of IkB in CHO cells overexpressing LAMP-2
Sat Aug 01 00:00:00 UTC 1998
A receptor for the selective uptake and degradation of proteins by lysosomes.
Science (New York, N.Y.)
Cuervo AM,Dice JF
51-2200 was used in Western blot to demonstrate that LAMP-2A/LGP96 overexpression in CHO cells can increase lysosomal proteolytic activity in vitro and in vivo
Fri Jul 26 00:00:00 UTC 1996
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.jpg?time=20250104?time=20250104 "LAMP-2A Antibody (51-2200) in IHC")
.jpg?time=20250104?time=20250104 "LAMP-2A Antibody (51-2200) in IHC")
.jpg?time=20250104?time=20250104 "LAMP-2A Antibody (51-2200) in WB")
.jpg?time=20250104?time=20250104 "LAMP-2A Antibody (51-2200) in WB")
