Proteintech

LAMR1/RPSA Polyclonal Antibody

LAMR1/RPSA Antibody in Immunocytochemistry (ICC/IF)

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LAMR1/RPSA Antibody (14533-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 14533-1-AP (LAMR1,RPSA antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

LAMR1/RPSA Antibody in Western Blot (WB)

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Product Details

14533-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LAMR1,RPSA Fusion Protein Ag6033 (1-295 aa encoded by BC050688)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against full length RPSA of human origin. This antibody is specific to RPSA (LAMR1).67LR derived from homo- or hetero- dimerization of a 37 kDa cytosolic precursor (37LRP)], most probably by fatty acid acylation. 37LRP is mostly found in the cytosol and nucleus [10] where it is involved in translational processes and maintenance of nuclear structures, respectively. 67LR is localized at the cell surface and it not only serves as a receptor for LM but also acts as a receptor for elastin, carbohydrates and the cellular prion protein.

Immunogen sequence: MSGALDVLQ MKEEDVLKFL AAGTHLGGTN LDFQMEQYIY KRKSDGIYII NLKRTWEKLL LAARAIVAIE NPADVSVISS RNTGQRAVLK FAAATGATPI AGRFTPGTFT NQIQATFREP RLLVVTDPRA DHQPLTEASY VNLPTIALCN TDSPLRYVDI AIPCNNKGAH SVGLMWWMLA REVLRMRGTI SREHPWEVMP DLYFYRDPEE IEKEEQAAAE KAVTKEEFQG EWTAPAPEFT ATQPEVADWS EGVQVPSVPI QQFPTEDWSA QPATEDWSAA PTAQATEWVG ATTDWS (1-295 aa encoded by B C050688)

Target Information

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Amelioration of gamma irradiation-induced salivary gland damage in mice using melatonin.

Journal of pineal research

Ren J,Zhu T,Wang Z,Lu L,Fan S

Fri Sep 01 00:00:00 UTC 2023

Theaflavin-3,3'-di-gallate represses prostate cancer by activating the PKCδ/aSMase signaling pathway through a 67 kDa laminin receptor.

Food & function

Sun L,Wen S,Li Q,Lai X,Chen R,Zhang Z,Cao J,Sun S

Wed Apr 20 00:00:00 UTC 2022

Theaflavin-3,3'-di-gallate represses prostate cancer by activating the PKCδ/aSMase signaling pathway through a 67 kDa laminin receptor.

Food & function

Sun L,Wen S,Li Q,Lai X,Chen R,Zhang Z,Cao J,Sun S

Wed Apr 20 00:00:00 UTC 2022

Theaflavin-3,3'-di-gallate represses prostate cancer by activating the PKCδ/aSMase signaling pathway through a 67 kDa laminin receptor.

Food & function

Sun L,Wen S,Li Q,Lai X,Chen R,Zhang Z,Cao J,Sun S

Wed Apr 20 00:00:00 UTC 2022

Theaflavin-3,3'-di-gallate represses prostate cancer by activating the PKCδ/aSMase signaling pathway through a 67 kDa laminin receptor.

Food & function

Sun L,Wen S,Li Q,Lai X,Chen R,Zhang Z,Cao J,Sun S

Wed Apr 20 00:00:00 UTC 2022

Strategies to Attenuate Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Pigment Epithelium-Derived Factor.

Human gene therapy

Zhang H,Li Z,Quan X,Liu X,Sun T,Wei T,Pan J,Liu Z,Wang M,Dong H,Zhang Z

Tue Mar 01 00:00:00 UTC 2022

Caveolae/rafts protect human cerebral microvascular endothelial cells from Streptococcus suis serotype 2 α-enolase-mediated injury.

Veterinary microbiology

Jiang H,Wu T,Liu J,Yu X,Liu H,Bao C,Liu M,Ji Y,Feng X,Gu J,Han W,Li N,Lei L

Mon Mar 01 00:00:00 UTC 2021

Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity.

Veterinary research