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Proteintech
LAP2 Polyclonal Antibody
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Product Details
14651-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LAP2 Fusion Protein Ag6247 (1-362 aa encoded by BC053675)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPEFLEDPS VLTKDKLKSE LVANNVTLPA GEQRKDVYVQ LYLQHLTARN RPPLPAGTNS KGPPDFSSDE EREPTPVLGS GAAAAGRSRA AVGRKATKKT DKPRQEDKDD LDVTELTNED LLDQLVKYGV NPGPIVGTTR KLYEKKLLKL REQGTESRSS TPLPTISSSA ENTRQNGSND SDRYSDNEED SKIELKLEKR EPLKGRAKTP VTLKQRRVEH NQSYSQAGIT ETEWTSGSSK GGPLQALTRE STRGSRRTPR KRVETSEHFR IDGPVISEST PIAETIMASS NESLVVNRVT GNFKHASPIL PITEFSDIPR RAPKKPLTRA EVGEKTEERR VERDILKEMF PYEASTPTGI SAS (1-362 aa encoded by BC053675)
Target Information
In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large, supramolecular assemblies called nuclear pore complexes through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. The attachment of the lamins to the inner nuclear membrane appears to occur through their association with 4 related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B and 1C share a high degree of sequence homology while LAP 2 is distinct from the others. LAP 1A/B bind lamins A, C and B1, while LAP 2 binds lamin B1 only. In addition to lamin binding, LAP 2 has been shown to bind to chromosomes. Phosphorylation of LAP 2 during mitosis inhibits binding to both lamins and chromosomes suggesting that LAP 2 plays an important role in nuclear envelope re-assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ31884; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; lamina-associated polypeptide 2; Lamina-associated polypeptide 2, isoform alpha; Lamina-associated polypeptide 2, isoform beta; Lamina-associated polypeptide 2, isoforms beta/gamma; LEM domain containing 4; Thymopoietin (lamina associated polypeptide 2); thymopoietin beta; Thymopoietin isoform alpha; Thymopoietin isoform beta; Thymopoietin, isoforms beta/gamma; Thymopoietin-related peptide isoform alpha; Thymopoietin-related peptide isoforms beta/gamma; TP alpha; TP beta; TP beta/gamma; TPRP isoform alpha; TPRP isoforms beta/gamma
Gene Aliases: CMD1T; LAP2; LEMD4; PRO0868; TMPO; TP
UniProt ID: (Human) P42166, (Rat) Q62733
Entrez Gene ID: (Human) 7112, (Rat) 25359
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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