Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 1
LAR4B Antibody (PA5-88966) in WB
Western blot analysis of LAR4B in extracts of various cell lines. Samples were incubated with LAR4B Polyclonal antibody (Product # PA5-88966) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-88966
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 519-738 of human LARP5 (NP_0559701)
Conjugate
Form
Liquid
Concentration
2.54 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805261
Product Specific Information
Immunogen sequence: PPKPPSPSFE LGLSSFPPLP GAAGNLKTED LFENRLSSLI IGPSKERTLS ADASVNTLPV VVSREPSVPA SCAVSATYER SPSPAHLPDD PKVAEKQRET HSVDRLPSAL TATACKSVQV NGAATELRKP SYAEICQRTS KEPPSSPLQP QKEQKPNTVG CGKEEKKLAE PAERYREPPA LKSTPGAPRD QRRPAGGRPS PSAMGKRLSR EQSTPPKSPQ; Positive Samples: 293T, U-87MG, HeLa, LO2, Mouse brain, Rat brain; Cellular Location: Cytoplasm, cytosol
Target Information
The LAR4B gene, more accurately referred to as LARP4B (La Ribonucleoprotein Domain Family Member 4B), is associated with RNA-binding proteins that are crucial for various aspects of RNA metabolism, including RNA stabilization, translation, and cellular stress responses. LARP4B belongs to the La-related protein family, which plays significant roles in maintaining RNA stability and enhancing translation efficiency of certain mRNAs. It has been identified as a target in cancer research due to its involvement in tumor biology, particularly regulating tumor suppressive pathways and interacting with microRNA networks. Studies have shown that LARP4B expression is downregulated in prostate cancer tissues, indicating its potential role as a tumor suppressor. Moreover, it is linked with liver cancer and survival rates, reflecting its importance in cellular growth and proliferation. The regulation of LARP4B and its interactions with other cellular components underline its potential therapeutic implications for cancer treatment.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: La ribonucleoprotein domain family member 4B; La ribonucleoprotein domain family member 5; La ribonucleoprotein domain family, member 4B; La ribonucleoprotein domain family, member 5; La-related protein 4B; La-related protein 5
Gene Aliases: A630096F19; AI256361; D13Wsu64e; KIAA0217; LARP4B; LARP5; RGD1310713
UniProt ID: (Human) Q92615, (Mouse) Q6A0A2
Entrez Gene ID: (Human) 23185, (Rat) 307070, (Mouse) 217980
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support