Proteintech

LARG Polyclonal Antibody

LARG Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

LARG Antibody (22441-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using ARHGEF12 antibody 22441-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

LARG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

22441-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LARG Fusion Protein Ag18211 (214-563 aa encoded by BC063117)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.49 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QRLLKEIQE AKKHIPQLQE QLSKATGSAQ DGAVVTPSRP LGDTLTVSEA ETDPGDVLGR TDCSSGDASR PSSDNADSPK SGPKERIYLE ENPEKSETIQ DTDTQSLVGS PSTRIAPHII GAEDDDFGTE HEQINGQCSC FQSIELLKSR PAHLAVFLHH VVSQFDPATL LCYLYSDLYK HTNSKETRRI FLEFHQFFLD RSAHLKVSVP DEMSADLEKR RPELIPEDLH RHYIQTMQER VHPEVQRHLE DFRQKRSMGL TLAESELTKL DAERDKDRLT LEKERTCAEQ IVAKIEEVLM TAQAVEEDKS STMQYVILMY MKHLGVKVKE PRNLEHKRGR IGFLPKIKQS M (214-563 aa encoded by BC063117)

Target Information

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.

International journal of molecular sciences

Sun H,Shen L,Zhang P,Lin F,Ma J,Wu Y,Yu H,Sun L

Tue Oct 04 00:00:00 UTC 2022

Regulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt/β-catenin signalling via interaction with Gli1.

British journal of pharmacology

Zhang F,Wang F,He J,Lian N,Wang Z,Shao J,Ding H,Tan S,Chen A,Zhang Z,Wang S,Zheng S

Tue Jun 01 00:00:00 UTC 2021

Leukemia-Associated Rho Guanine Nucleotide Exchange Factor and Ras Homolog Family Member C Play a Role in Glioblastoma Cell Invasion and Resistance.

The American journal of pathology

Ding Z,Dong Z,Yang Y,Fortin Ensign SP,Sabit H,Nakada M,Ruggieri R,Kloss JM,Symons M,Tran NL,Loftus JC

Thu Oct 01 00:00:00 UTC 2020

Leukemia-Associated Rho Guanine Nucleotide Exchange Factor and Ras Homolog Family Member C Play a Role in Glioblastoma Cell Invasion and Resistance.

The American journal of pathology

Ding Z,Dong Z,Yang Y,Fortin Ensign SP,Sabit H,Nakada M,Ruggieri R,Kloss JM,Symons M,Tran NL,Loftus JC

Thu Oct 01 00:00:00 UTC 2020

RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases.

Proceedings of the National Academy of Sciences of the United States of America

Shi GX,Yang WS,Jin L,Matter ML,Ramos JW

Tue Jan 09 00:00:00 UTC 2018

RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases.

Proceedings of the National Academy of Sciences of the United States of America

Shi GX,Yang WS,Jin L,Matter ML,Ramos JW

Tue Jan 09 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: leukemia-associated rho guanine nucleotide exchange factor; Leukemia-associated RhoGEF; Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine nucleotide exchange factor 12

View more View less

Gene Aliases: ARHGEF12; KIAA0382; LARG; PRO2792

View more View less

UniProt ID: (Human) Q9NZN5

View more View less

Entrez Gene ID: (Human) 23365

View more View less

Function(s)

G-protein coupled receptor binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity protein binding

Process(es)

G-protein coupled receptor signaling pathway regulation of Rho protein signal transduction intracellular signal transduction positive regulation of apoptotic process positive regulation of GTPase activity regulation of small GTPase mediated signal transduction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

LARG Polyclonal Antibody

LARG Antibody (22441-1-AP) in ICC/IF

Product Details

22441-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!