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Proteintech
LARP1 Polyclonal Antibody
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Product Details
13708-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LARP1 Fusion Protein Ag4645 (1-283 aa encoded by BC033856)
Conjugate
Form
Liquid
Concentration
0.51 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPRKRKTRH SSNPPLESHV GWVMDSREHR PRTASISSSP SEGTPTVGSY GCTPQSLPKF QHPSHELLKE NGFTQHVYHK YRRRCLNERK RLGIGQSQEM NTLFRFWSFF LRDHFNKKMY EEFKQLALED AKEGYRYGLE CLFRYYSYGL EKKFRLDIFK DFQEETVKDY EAGQLYGLEK FWAFLKYSKA KNLDIDPKLQ EYLGKFRRLE DFRVDPPMGE EGNHKRHSVV AGGGGGEGRK RCPSQSSSRP AAMISQPPTP PTGQPVREDA KWTSQHSNTQ TLGK (1-283 aa encoded by BC033856)
Target Information
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CG42551-PA; CG42551-PB; CG42551-PD; CG42551-PE; CG42551-PF; CG42551-PG; CG42551-PH; dLarp; drosophila La related protein; La related protein; La ribonucleoprotein domain family member 1; La ribonucleoprotein domain family, member 1; La-related protein; La-related protein 1; larp-PA; larp-PB; larp-PD; larp-PE; larp-PF; larp-PG; larp-PH; lethal (3) S003108; lethal (3) S022529; meteor
Gene Aliases: 0031/08; 0225/29; 1810024J12Rik; 3110040D16Rik; BcDNA:LD02611; CG14065; CG14066; CG42551; dlarp; Dmel\CG42551; Dmel_CG42551; KIAA0731; l(3)S003108; l(3)S022529; LARP; LARP1; mKIAA0731; RGD1306683
UniProt ID: (Human) Q6PKG0, (Mouse) Q6ZQ58, (Fruit fly) Q9VAW5
Entrez Gene ID: (Human) 23367, (Mouse) 73158, (Rat) 303158, (Fruit fly) 53567
translational initiation
cell proliferation
positive regulation of macroautophagy
TOR signaling
positive regulation of viral genome replication
positive regulation of translation
cell-cell adhesion
mitochondrion inheritance
spindle assembly involved in male meiosis
mitotic chromosome condensation
male meiosis
salivary gland cell autophagic cell death
syncytial blastoderm mitotic cell cycle
autophagic cell death
spindle assembly
centrosome separation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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