Proteintech

LARS2 Polyclonal Antibody

LARS2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

LARS2 Antibody (17097-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 17097-1-AP (LARS2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

LARS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

LARS2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17097-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LARS2 Fusion Protein Ag10576 (554-903 aa encoded by BC025989)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VDLYIGGKE HAVMHLFYAR FFSHFCHDQK MVKHREPFHK LLAQGLIKGQ TFRLPSGQYL QREEVDLTGS VPVHAKTKEK LEVTWEKMSK SKHNGVDPEE VVEQYGIDTI RLYILFAAPP EKDILWDVKT DALPGVLRWQ QRLWTLTTRF IEARASGKSP QPQLLSNKEK AEARKLWEYK NSVISQVTTH FTEDFSLNSA ISQLMGLSNA LSQASQSVIL HSPEFEDALC ALMVMAAPLA PHVTSEIWAG LALVPRKLCA HYTWDASVLL QAWPAVDPEF LQQPEVVQMA VLINNKACGK IPVPQQVARD QDKVHEFVLQ SELGVRLLQG RSIKKSFLSP RTALINFLVQ D (554-903 aa encoded by BC025989)

Target Information

This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle.

Redox biology

López-Soldado I,Torres AG,Ventura R,Martínez-Ruiz I,Díaz-Ramos A,Planet E,Cooper D,Pazderska A,Wanic K,O'Hanlon D,O'Gorman DJ,Carbonell T,Ribas de Pouplana L,Nolan JJ,Zorzano A,Hernández-Alvarez MI

Mon May 01 00:00:00 UTC 2023

RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation.

Nucleic acids research

Peng GX,Mao XL,Cao Y,Yao SY,Li QR,Chen X,Wang ED,Zhou XL

Fri Dec 09 00:00:00 UTC 2022

RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation.

Nucleic acids research

Peng GX,Mao XL,Cao Y,Yao SY,Li QR,Chen X,Wang ED,Zhou XL

Fri Dec 09 00:00:00 UTC 2022

LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells.

Oxidative medicine and cellular longevity

Feng S,Wan S,Liu S,Wang W,Tang M,Bai L,Zhu Y

Fri May 20 00:00:00 UTC 2022

Single-Cell Transcriptional Profiling Reveals Sex and Age Diversity of Gene Expression in Mouse Endothelial Cells.

Frontiers in genetics

Huang X,Shen W,Veizades S,Liang G,Sayed N,Nguyen PK

Wed Mar 10 00:00:00 UTC 2021

Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.

Molecular cell

Kim SH,Choi JH,Wang P,Go CD,Hesketh GG,Gingras AC,Jafarnejad SM,Sonenberg N

Thu Jan 21 00:00:00 UTC 2021

Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.

Molecular cell

Kim SH,Choi JH,Wang P,Go CD,Hesketh GG,Gingras AC,Jafarnejad SM,Sonenberg N

Thu Jan 21 00:00:00 UTC 2021

Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNA^His mutation.

The Journal of biological chemistry

Gong S,Wang X,Meng F,Cui L,Yi Q,Zhao Q,Cang X,Cai Z,Mo JQ,Liang Y,Guan MX

Fri Jan 24 00:00:00 UTC 2020

Single-Cell RNA Sequencing Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells.

Circulation

Paik DT,Tian L,Williams IM,Rhee S,Zhang H,Liu C,Mishra R,Wu SM,Red-Horse K,Wu JC

Tue Nov 10 00:00:00 UTC 2020

Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.

Nucleic acids research

Zhang Q,Zhang L,Chen D,He X,Yao S,Zhang Z,Chen Y,Guan MX

Fri Nov 16 00:00:00 UTC 2018

Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.

Nucleic acids research

Zhang Q,Zhang L,Chen D,He X,Yao S,Zhang Z,Chen Y,Guan MX

Fri Nov 16 00:00:00 UTC 2018

The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells.

EMBO molecular medicine

Perli E,Giordano C,Pisano A,Montanari A,Campese AF,Reyes A,Ghezzi D,Nasca A,Tuppen HA,Orlandi M,Di Micco P,Poser E,Taylor RW,Colotti G,Francisci S,Morea V,Frontali L,Zeviani M,d'Amati G

Sat Feb 01 00:00:00 UTC 2014

The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells.

EMBO molecular medicine

Perli E,Giordano C,Pisano A,Montanari A,Campese AF,Reyes A,Ghezzi D,Nasca A,Tuppen HA,Orlandi M,Di Micco P,Poser E,Taylor RW,Colotti G,Francisci S,Morea V,Frontali L,Zeviani M,d'Amati G

Sat Feb 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: leucine translase; leucine tRNA ligase 2, mitochondrial; leucine tRNA ligase 2, mitocondrial; Leucine--tRNA ligase, mitochondrial; Leucyl-tRNA synthetase; leucyl-tRNA synthetase 2; LeuRS; probable leucyl-tRNA synthetase, mitochondrial

View more View less

Gene Aliases: KIAA0028; LARS2; LEURS; mtLeuRS; PRLTS4

View more View less

UniProt ID: (Human) Q15031

View more View less

Entrez Gene ID: (Human) 23395

View more View less

Function(s)

aminoacyl-tRNA editing activity leucine-tRNA ligase activity ATP binding

Process(es)

tRNA aminoacylation for protein translation leucyl-tRNA aminoacylation regulation of translational fidelity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

LARS2 Polyclonal Antibody

LARS2 Antibody (17097-1-AP) in ICC/IF

Product Details

17097-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!