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Product Details
11873-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LDB2 Fusion Protein Ag2460 (1-373 aa encoded by BC034019)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSSTPHDPF YSSPFGPFYR RHTPYMVQPE YRIYEMNKRL QSRTEDSDNL WWDAFATEFF EDDATLTLSF CLEDGPKRYT IGRTLIPRYF STVFEGGVTD LYYILKHSKE SYHNSSITVD CDQCTMVTQH GKPMFTKVCT EGRLILEFTF DDLMRIKTWH FTIRQYRELV PRSILAMHAQ DPQVLDQLSK NITRMGLTNF TLNYLRLCVI LEPMQELMSR HKTYNLSPRD CLKTCLFQKW QRMVAPPAEP TRQPTTKRRK RKNSTSSTSN SSAGNNANST GSKKKTTAAN LSLSSQVPDV MVVGEPTLMG GEFGDEDERL ITRLENTQYD AANGMDDEED FNNSPALGNN SPWNSKPPAT QETKSENPPP QASQ (1-373 aa encoded by BC034019)
Target Information
Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins. These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes. The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 and Clim2/Lbd1/Nli; and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Carboxyl-terminal LIM domain-binding protein 1; CLIM-1; LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; LIM domain-binding protein 2
Gene Aliases: AI035351; AW146358; CLIM1; CLP-36; LDB-2; LDB1; LDB2; Ldb3
UniProt ID: (Human) O43679, (Mouse) O55203
Entrez Gene ID: (Human) 9079, (Rat) 289664, (Mouse) 16826
hair follicle development
epithelial structure maintenance
somatic stem cell population maintenance
positive regulation of cellular component biogenesis
positive regulation of transcription from RNA polymerase II promoter
regulation of nucleic acid-templated transcription
regulation of transcription from RNA polymerase II promoter
regulation of cell migration
regulation of kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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