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Product Details
PA5-31346
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human LDB2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.73 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2548820
Product Specific Information
Recommended positive controls: HeLa, mouse brain.
Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (98%), Chicken (97%), Rhesus Monkey (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins. These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes. The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 and Clim2/Lbd1/Nli; and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Carboxyl-terminal LIM domain-binding protein 1; CLIM-1; LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; LIM domain-binding protein 2
Gene Aliases: AI035351; AW146358; CLIM1; CLP-36; LDB-2; LDB1; LDB2; Ldb3
UniProt ID: (Human) O43679, (Mouse) O55203
Entrez Gene ID: (Human) 9079, (Mouse) 16826
hair follicle development
regulation of transcription from RNA polymerase II promoter
epithelial structure maintenance
somatic stem cell population maintenance
positive regulation of cellular component biogenesis
positive regulation of transcription from RNA polymerase II promoter
regulation of nucleic acid-templated transcription
regulation of cell migration
regulation of kinase activity
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