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Product Details
PA5-70568
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human LDLRAD4 (aa 257-306)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2691228
Product Specific Information
This target displays homology in the following species: Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 86%; Rat: 93%
Target Information
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: clone 22; Low-density lipoprotein receptor class A domain-containing protein 4
Gene Aliases: C18orf1; LDLRAD4
UniProt ID: (Human) O15165
Entrez Gene ID: (Human) 753
negative regulation of epithelial to mesenchymal transition
negative regulation of SMAD protein complex assembly
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of pathway-restricted SMAD protein phosphorylation
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