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Proteintech
LEFTY2 Polyclonal Antibody
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Product Details
13991-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LEFTY2 Fusion Protein Ag5073 (24-366 aa encoded by BC035718)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EEQLLGSLL RQLQLSEVPV LDRADMEKLV IPAHVRAQYV VLLRRSHGDR SRGKRFSQSF REVAGRFLAS EASTHLLVFG MEQRLPPNSE LVQAVLRLFQ EPVPKAALHR HGRLSPRSAQ ARVTVEWLRV RDDGSNRTSL IDSRLVSVHE SGWKAFDVTE AVNFWQQLSR PRQPLLLQVS VQREHLGPLA SGAHKLVRFA SQGAPAGLGE PQLELHTLDL RDYGAQGDCD PEAPMTEGTR CCRQEMYIDL QGMKWAKNWV LEPPGFLAYE CVGTCQQPPE ALAFNWPFLG PRQCIASETA SLPMIVSIKE GGRTRPQVVS LPNMRVQKCS CASDGALVPR RLQP (24-366 aa encoded by BC035718)
Target Information
Left-right determination factor 1 and 2 (Lefty1/2) belong to the TGF-beta superfamily of proteins and are responsible for determination of left-right positioning of visceral organs during embryogenesis. Lefty1 acts as a regulator of Lefty2 and NODAL as the lack of the former resulted in bilateral expression of nodal, lefty2 and Pitx2 (a homeobox gene normally expressed on the left side and blocks the signal for leftness). Lefty2 may play a role in endometrial bleeding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: endometrial bleeding associated factor; Endometrial bleeding-associated factor; Left-right determination factor 2; Left-right determination factor A; Left-right determination factor B; left-right determination, factor A; MGC46222; Protein lefty-2; Protein lefty-A; Protein lefty-B; TGF-beta-4; Transforming growth factor beta-4
Gene Aliases: 6030463A22Rik; AV214969; EBAF; Ebaf2; LEFTA; Leftb; LEFTY2; LEFTYA; PSEC0024; TGFB4
UniProt ID: (Human) O00292, (Mouse) P57785
Entrez Gene ID: (Human) 7044, (Rat) 289316, (Mouse) 320202
platelet degranulation
transforming growth factor beta receptor signaling pathway
multicellular organism development
positive regulation of pathway-restricted SMAD protein phosphorylation
cell growth
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
determination of left/right symmetry
biological_process
negative regulation of cell proliferation
anterior/posterior axis specification
response to retinoic acid
cell migration involved in gastrulation
negative regulation of nodal receptor complex assembly
growth
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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