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Proteintech
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Immunogen sequence: RALNQYQAQL GEPRPGLGPR EDIQRFILRS LGEKRQLYYA MEHLGTSFKD PDPWTPAALI PEALREKLRE DQEKRPWDHE PVKPKPLTYW KDVLLLEGVT LTQDSRQLNG SERAVLDGLL TPAECGVLLQ LAKDAAGAGA RSGYRGRRSP HTPHERFEGL TVLKAAQLAR AGTVGSQGAK LLLEVSERVR TLTQAYFSPE RPLHLSFTHL VCRSAIEGEQ EQRMDLSHPV HADNCVLDPD TGECWREPPA YTYRDYSGLL YLNDDFQGGD LFFTEPNALT VTARVRPRCG RLVAFSSGVE NPHGVWAVTR GRRCALALWH TWAPEHREQE WIEAKELLQE SQEEEEEEEE EMPSKDPSPE PPSRRHQRVQ DKTGRAPRVR EEL
The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: gene rich cluster, B; leprecan-like 2; Leprecan-like protein 2; procollagen-proline 3-dioxygenase; Prolyl 3-hydroxylase 3; Protein B
Gene Aliases: GRCB; HSU47926; LEPREL2; P3H3
UniProt ID: (Human) Q8IVL6
Entrez Gene ID: (Human) 10536, (Rat) 297595
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