Proteintech

LETM1 Polyclonal Antibody

LETM1 Antibody in Immunocytochemistry (ICC/IF)

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LETM1 Antibody (16024-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using (Product # 16024-1-AP) (LETM1 antibody), at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). F-actin is stained using CL555-phalloidin (red) and DNA is stained by DAPI (blue).

LETM1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

LETM1 Antibody in Immunoprecipitation (IP)

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Product Details

16024-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LETM1 Fusion Protein Ag8861 (391-739 aa encoded by BC021208)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EDRLRGQLK QWLDLHLHQE IPTSLLILSR AMYLPDTLSP ADQLKSTLQT LPEIVAKEAQ VKVAEVEGEQ VDNKAKLEAT LQEEAAIQQE HREKELQKRS EVAKDFEPER VVAAPQRPGT EPQPEMPDTV LQSETLKDTA PVLEGLKEEE ITKEEIDILS DACSKLQEQK KSLTKEKEEL ELLKEDVQDY SEDLQEIKKE LSKTGEEKYV EESKASKRLT KRVQQMIGQI DGLISQLEMD QQAGKLAPAN GMPTGENVIS VAELINAMKQ VKHIPESKLT SLAAALDENK DGKVNIDDLV KVIELVDKED VHISTSQVAE IVATLEKEEK VEEKEKAKEK AEKEVAEVKS (391-739 aa encoded by BC021208)

Target Information

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Multiomics Approach Reveals an Important Role of BNIP3 in Myocardial Remodeling and the Pathogenesis of Heart Failure with Reduced Ejection Fraction.

Cells

Chaanine AH,Higgins L,Lauterboeck L,Markowski T,Yang Q,Delafontaine P

Fri May 06 00:00:00 UTC 2022

Multiomics Approach Reveals an Important Role of BNIP3 in Myocardial Remodeling and the Pathogenesis of Heart Failure with Reduced Ejection Fraction.

Cells

Chaanine AH,Higgins L,Lauterboeck L,Markowski T,Yang Q,Delafontaine P

Fri May 06 00:00:00 UTC 2022

Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.

Nature communications

Chern T,Achilleos A,Tong X,Hill MC,Saltzman AB,Reineke LC,Chaudhury A,Dasgupta SK,Redhead Y,Watkins D,Neilson JR,Thiagarajan P,Green JBA,Malovannaya A,Martin JF,Rosenblatt DS,Poché RA

Mon Jan 10 00:00:00 UTC 2022

Sunitinib and Pterostilbene Combination Treatment Exerts Antitumor Effects in Gastric Cancer via Suppression of PDZD8.

International journal of molecular sciences

Hojo Y,Kishi S,Mori S,Fujiwara-Tani R,Sasaki T,Fujii K,Nishiguchi Y,Nakashima C,Luo Y,Shinohara H,Kuniyasu H

Mon Apr 04 00:00:00 UTC 2022

A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance.

Science advances

Rossetti G,Ermer JA,Stentenbach M,Siira SJ,Richman TR,Milenkovic D,Perks KL,Hughes LA,Jamieson E,Xiafukaiti G,Ward NC,Takahashi S,Gray N,Viola HM,Hool LC,Rackham O,Filipovska A

Fri Sep 24 00:00:00 UTC 2021

Minor contribution of NCX to Na⁺-Ca²⁺ exchange activity in brain mitochondria.

Cell calcium

Takeuchi A,Matsuoka S

Tue Jun 01 00:00:00 UTC 2021

Total Matrix Ca²⁺ Modulates Ca²⁺ Efflux via the Ca²⁺/H⁺ Exchanger in Cardiac Mitochondria.

Frontiers in physiology

Natarajan GK,Glait L,Mishra J,Stowe DF,Camara AKS,Kwok WM

Thu Dec 22 00:00:00 UTC 2022

Evaluation of cancer-derived myocardial impairments using a mouse model.

Oncotarget

Miyagawa Y,Nukaga S,Mori T,Fujiwara-Tani R,Fujii K,Mori S,Goto K,Kishi S,Sasaki T,Nakashima C,Ohmori H,Kawahara I,Luo Y,Kuniyasu H

Tue Oct 13 00:00:00 UTC 2020

Intake of medium-chain fatty acids induces myocardial oxidative stress and atrophy.

Lipids in health and disease

Miyagawa Y,Mori T,Goto K,Kawahara I,Fujiwara-Tani R,Kishi S,Sasaki T,Fujii K,Ohmori H,Kuniyasu H

Sat Nov 17 00:00:00 UTC 2018

Intake of medium-chain fatty acids induces myocardial oxidative stress and atrophy.

Lipids in health and disease

Miyagawa Y,Mori T,Goto K,Kawahara I,Fujiwara-Tani R,Kishi S,Sasaki T,Fujii K,Ohmori H,Kuniyasu H

Sat Nov 17 00:00:00 UTC 2018

The mitochondrial Na⁺/Ca²⁺ exchanger is essential for Ca²⁺ homeostasis and viability.

Nature

Luongo TS,Lambert JP,Gross P,Nwokedi M,Lombardi AA,Shanmughapriya S,Carpenter AC,Kolmetzky D,Gao E,van Berlo JH,Tsai EJ,Molkentin JD,Chen X,Madesh M,Houser SR,Elrod JW

Thu May 04 00:00:00 UTC 2017

The mitochondrial Na⁺/Ca²⁺ exchanger is essential for Ca²⁺ homeostasis and viability.

Nature

Luongo TS,Lambert JP,Gross P,Nwokedi M,Lombardi AA,Shanmughapriya S,Carpenter AC,Kolmetzky D,Gao E,van Berlo JH,Tsai EJ,Molkentin JD,Chen X,Madesh M,Houser SR,Elrod JW

Thu May 04 00:00:00 UTC 2017

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.

Cell reports

Luongo TS,Lambert JP,Yuan A,Zhang X,Gross P,Song J,Shanmughapriya S,Gao E,Jain M,Houser SR,Koch WJ,Cheung JY,Madesh M,Elrod JW

Tue Jul 07 00:00:00 UTC 2015

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.

Cell reports

Luongo TS,Lambert JP,Yuan A,Zhang X,Gross P,Song J,Shanmughapriya S,Gao E,Jain M,Houser SR,Koch WJ,Cheung JY,Madesh M,Elrod JW

Tue Jul 07 00:00:00 UTC 2015

Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Jiang D,Zhao L,Clish CB,Clapham DE

Tue Jun 11 00:00:00 UTC 2013

Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Jiang D,Zhao L,Clish CB,Clapham DE

Tue Jun 11 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Electroneutral mitochondrial K(+)/H(+)exchanger; KHE; leucine zipper-EF-hand containing transmembrane protein 1; Leucine zipper-EF-hand-containing transmembrane protein 1; Mdm38 homolog; Mitochondrial proton/calcium exchanger protein

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Gene Aliases: LETM1

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UniProt ID: (Human) O95202

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Entrez Gene ID: (Human) 3954

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Function(s)

calcium ion binding protein binding ribosome binding

Process(es)

cristae formation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LETM1 Polyclonal Antibody

LETM1 Antibody (16024-1-AP) in ICC/IF

Product Details

16024-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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