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Product Details
PA5-20311
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid synthetic peptide from near the amino terminus of human FAIM2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153595
Product Specific Information
A suggested positive control is EL4 cell lysate.
PA5-20311 can be used with blocking peptide PEP-0431.
Target Information
LFG, a seven transmembrane spanning protein, is a recently identified member of a family whose members can inhibit apoptotic cell death induced by Fas receptor. LFG is a human homolog of rat NMP35 and consists of a conserved transmembrane domain and a small cytoplasmic domain. Reports have shown that LFG protects the cell from Fas-mediated neuronal cell death in a novel way. LFG binds to Fas receptor but doesn't have any effect in reducing Fas expression or decreasing the ability of FADD binding to the receptor. Furthermore, LFG doesn't protect the cells from TNF-alpha mediated cell death process. Although LFG is ubiquitously expressed, Northern blot analysis detected an increased expression in hippocampus and other neural tissues, suggesting a protective role in neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Fas apoptotic inhibitory molecule 2; lifeguard; Neural membrane protein 35; protein lifeguard; Protein lifeguard 2; Transmembrane BAX inhibitor motif-containing protein 2
Gene Aliases: 2900002L20Rik; FAIM2; KIAA0950; LFG; LFG2; NGP35; NMP25; NMP35; TMBIM2
UniProt ID: (Human) Q9BWQ8, (Mouse) Q8K097, (Rat) O88407
Entrez Gene ID: (Human) 23017, (Mouse) 72393, (Rat) 246274
response to ischemia
apoptotic process
cerebellum development
cerebellar Purkinje cell layer development
cerebellar granular layer development
cerebellar Purkinje cell differentiation
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
negative regulation of apoptotic signaling pathway
negative regulation of apoptotic process
central nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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