OriGene

LGALS9 Monoclonal Antibody (OTI1D12), TrueMAB™

View all (43) Galectin 9 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CF806323

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

OTI1D12

Immunogen

Full length human recombinant protein of human LGALS9 produced in HEK293T cell.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H and RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ecalectin; Gal-9; Gal9; Galectin-9; Galectin9; HOM HD 21; lectin, galactoside binding soluble 9; lectin, galactoside-binding, soluble, 9; Tumor antigen HOM-HD-21; urate transporter/channel protein

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Gene Aliases: HUAT; LGALS9; LGALS9A

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UniProt ID: (Human) O00182

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Entrez Gene ID: (Human) 3965

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Function(s)
signal transducer activity galactose binding enzyme binding carbohydrate binding disaccharide binding
Process(es)
natural killer cell tolerance induction chemotaxis inflammatory response female pregnancy positive regulation of gene expression negative regulation of gene expression response to lipopolysaccharide regulation of interleukin-4 production regulation of interleukin-5 production negative regulation of chemokine production negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-4 production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway p38MAPK cascade positive regulation of NF-kappaB import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of mast cell degranulation negative regulation of natural killer cell mediated cytotoxicity negative regulation of activated T cell proliferation positive regulation of viral entry into host cell positive regulation of interleukin-1 beta secretion positive regulation of NF-kappaB transcription factor activity maternal process involved in female pregnancy positive regulation of activated T cell autonomous cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade response to interleukin-1 cellular response to interferon-gamma positive regulation of transforming growth factor beta production positive regulation of monocyte chemotactic protein-1 production mature conventional dendritic cell differentiation cellular response to virus regulation of p38MAPK cascade positive regulation of interferon-gamma secretion positive regulation of tumor necrosis factor secretion positive regulation of interleukin-8 secretion positive regulation of dendritic cell chemotaxis negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of interleukin-13 secretion positive regulation of dendritic cell apoptotic process positive regulation of interleukin-6 secretion positive regulation of interleukin-10 secretion positive regulation of interleukin-12 secretion positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of dendritic cell differentiation positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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