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Product Details
PA1-20450
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 19 amino acid peptide from 2nd cytoplasmic domain of human LGR4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_559110
Product Specific Information
PA1-20450 detects G Protein-Coupled Receptor GPR48 in human samples.
Target Information
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. GPCR LGR4 is a member of this family (subfamily Orphan-A). Its expression has been documented in human brain, adrenal, heart, kidney, liver, skeletal muscle, ovary, pancreas, placenta, prostate, spleen, stomach, testis, thyroid, and spinal cord.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein-coupled receptor 48; G-protein coupled receptor 48; leucine-rich repeat containing G protein-coupled receptor 4; Leucine-rich repeat-containing G-protein coupled receptor 4
Gene Aliases: BNMD17; GPR48; LGR4
UniProt ID: (Human) Q9BXB1
Entrez Gene ID: (Human) 55366
osteoblast differentiation
hair follicle development
G-protein coupled receptor signaling pathway
spermatogenesis
bone mineralization
male genitalia development
circadian regulation of gene expression
negative regulation of toll-like receptor signaling pathway
intestinal stem cell homeostasis
innate immune response
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
bone remodeling
digestive tract development
negative regulation of cytokine secretion
canonical Wnt signaling pathway involved in metanephric kidney development
cell differentiation involved in metanephros development
metanephric glomerulus development
metanephric nephron tubule morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of canonical Wnt signaling pathway
epithelial cell proliferation involved in renal tubule morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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