Proteintech

LHCGR Polyclonal Antibody

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LHCGR Antibody (19968-1-AP) in WB

Mouse testis tissue were subjected to SDS PAGE followed by western blot with 19968-1-AP (LHCGR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

LHCGR Antibody in Immunoprecipitation (IP)

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Product Details

19968-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

Assay-dependent

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

LHCGR encodes the receptor for both luteinizing hormone and choriogonadotropin. It is family 1 of G-protein coupled receptors, FSH/LSH/TSH superfamily, and its basic function is acting as luteinizing hormone/choriogonadotropin receptor (gonadotropin receptor). Regulating the development and function of Leyding cells in males. It also plays a role in male secondary sexual characterdevelopment. Mutations in this gonadotropinreceptor results in disorders of male secondary sexual characteristic development, such as familial male precocious puperty and male pseudohermaphtoditism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Effects of chronic dichlorodiphenyldichloroethylene exposure on testosterone secretion and steroidogenic pathway in the male gonad.

Biology of reproduction

Molina EM,Kavazis AN,Mendonça MT,Akingbemi BT

Tue Jul 11 00:00:00 UTC 2023

Role and mechanism of the p-JAK2/p-STAT3 signaling pathway in follicular development in PCOS rats.

General and comparative endocrinology

Wang H,Feng X,Wang T,Pan J,Zheng Z,Su Y,Weng H,Zhang L,Chen L,Zhou L,Zheng L

Sun Jan 01 00:00:00 UTC 2023

Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis.

Frontiers in endocrinology

Geng T,Sun Y,Cheng L,Cao Y,Zhang M,Hong Z,Ma L,Zhang Y

Tue May 24 00:00:00 UTC 2022

Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis.

Frontiers in endocrinology

Geng T,Sun Y,Cheng L,Cao Y,Zhang M,Hong Z,Ma L,Zhang Y

Tue May 24 00:00:00 UTC 2022

Acute hypoxia induced dysregulation of clock-controlled ovary functions.

Frontiers in physiology

Ding M,Lu Y,Huang X,Xing C,Hou S,Wang D,Zhang Y,Wang W,Zhang C,Zhang M,Meng F,Liu K,Liu G,Zhao J,Song L

Tue Sep 10 00:00:00 UTC 2024

Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway.

Particle and fibre toxicology

Jin H,Yan M,Pan C,Liu Z,Sha X,Jiang C,Li L,Pan M,Li D,Han X,Ding J

Thu Feb 17 00:00:00 UTC 2022

Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure.

Basic & clinical pharmacology & toxicology

Zheng S,Ma M,Chen Y,Li M

Tue Feb 01 00:00:00 UTC 2022

Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells.

Journal of assisted reproduction and genetics

Wan YT,Liu S,Zhao SK,Luo YY,Lv YS,Qu DN,Liu MH,Li Y

Thu Apr 01 00:00:00 UTC 2021

Effects of increasing intake of soybean oil on synthesis of testosterone in Leydig cells.

Nutrition & metabolism

Su Y,Tian Z,Qi X,Luo D,Liu L,Liu S,Zheng D,Wei F,He Z,Guan Q

Wed May 26 00:00:00 UTC 2021

Effects of increasing intake of soybean oil on synthesis of testosterone in Leydig cells.

Nutrition & metabolism

Su Y,Tian Z,Qi X,Luo D,Liu L,Liu S,Zheng D,Wei F,He Z,Guan Q

Wed May 26 00:00:00 UTC 2021

MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα.

Cell death & disease

Wang YM,Wu Y,Zheng YF,Wang HY

Mon Oct 25 00:00:00 UTC 2021

Evaluation of carvacrol on pituitary and sexual hormones and their receptors in the testicle of male diabetic rats.

Human & experimental toxicology

Shoorei H,Khaki A,Shokoohi M,Khaki AA,Alihemmati A,Moghimian M,Abtahi-Eivary SH

Sat Aug 01 00:00:00 UTC 2020

La₂O₃ Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.

International journal of nanomedicine

Yuan L,Li Q,Bai D,Shang X,Hu F,Chen Z,An T,Chen Y,Zhang X

Thu Jul 23 00:00:00 UTC 2020

Placental biology of Down syndrome in relation to increased gene dosage.

Hong Kong medical journal = Xianggang yi xue za zhi

Wong OGW,Ngan HYS,Cheung ANY

Thu Aug 01 00:00:00 UTC 2019

β-hCG promotes epithelial ovarian cancer metastasis through ERK/MMP2 signaling pathway.

Cell cycle (Georgetown, Tex.)

Wu W,Gao H,Li X,Peng S,Yu J,Liu N,Zhan G,Zhu Y,Wang K,Guo X

Tue Jan 01 00:00:00 UTC 2019

Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization.

The American journal of pathology

Wong OGW,Cheung CLY,Ip PPC,Ngan HYS,Cheung ANY

Mon Oct 01 00:00:00 UTC 2018

Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization.

The American journal of pathology

Wong OGW,Cheung CLY,Ip PPC,Ngan HYS,Cheung ANY

Mon Oct 01 00:00:00 UTC 2018

Gestational and lactational exposure to di-isobutyl phthalate via diet in maternal mice decreases testosterone levels in male offspring.

Chemosphere

Wang X,Sheng N,Cui R,Zhang H,Wang J,Dai J

Sat Apr 01 00:00:00 UTC 2017

Gestational and lactational exposure to di-isobutyl phthalate via diet in maternal mice decreases testosterone levels in male offspring.

Chemosphere

Wang X,Sheng N,Cui R,Zhang H,Wang J,Dai J

Sat Apr 01 00:00:00 UTC 2017

Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.

International journal of molecular sciences

Liu Y,Su X,Hao J,Chen M,Liu W,Liao X,Li G

Wed Jan 13 00:00:00 UTC 2016

Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.

International journal of molecular sciences

Liu Y,Su X,Hao J,Chen M,Liu W,Liao X,Li G

Wed Jan 13 00:00:00 UTC 2016

Neonatal exposure to 17α-ethynyl estradiol affects ovarian gene expression and disrupts reproductive cycles in female rats.

Reproductive toxicology (Elmsford, N.Y.)

Nozawa K,Nagaoka K,Zhang H,Usuda K,Okazaki S,Taya K,Yoshida M,Watanabe G

Tue Jul 01 00:00:00 UTC 2014

Neonatal exposure to 17α-ethynyl estradiol affects ovarian gene expression and disrupts reproductive cycles in female rats.

Reproductive toxicology (Elmsford, N.Y.)

Nozawa K,Nagaoka K,Zhang H,Usuda K,Okazaki S,Taya K,Yoshida M,Watanabe G

Tue Jul 01 00:00:00 UTC 2014

Neonatal exposure to 17α-ethynyl estradiol affects ovarian gene expression and disrupts reproductive cycles in female rats.

Reproductive toxicology (Elmsford, N.Y.)

Nozawa K,Nagaoka K,Zhang H,Usuda K,Okazaki S,Taya K,Yoshida M,Watanabe G

Tue Jul 01 00:00:00 UTC 2014

Neonatal exposure to 17α-ethynyl estradiol affects ovarian gene expression and disrupts reproductive cycles in female rats.

Reproductive toxicology (Elmsford, N.Y.)

Nozawa K,Nagaoka K,Zhang H,Usuda K,Okazaki S,Taya K,Yoshida M,Watanabe G

Tue Jul 01 00:00:00 UTC 2014

The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation.

PloS one

Ball CB,Rodriguez KF,Stumpo DJ,Ribeiro-Neto F,Korach KS,Blackshear PJ,Birnbaumer L,Ramos SB

Thu Jan 22 00:00:00 UTC 2015

The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation.

PloS one

Ball CB,Rodriguez KF,Stumpo DJ,Ribeiro-Neto F,Korach KS,Blackshear PJ,Birnbaumer L,Ramos SB

Thu Jan 22 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: HCG receptor; hypergonadotropic hypogonadism; LH receptor; LH/CG-R; LHR; LSH-R; Luteinizing hormone receptor; Lutropin receptor; Lutropin-choriogonadotropic hormone receptor; lutropin/choriogonadotropin receptor

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Gene Aliases: Gpcr19-rs1; HHG; LCGR; LGR2; LH-R; LH/CG-R; LH/CGR; LHCGR; LHR; LHRHR; LSH-R; LSHR; ULG5

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UniProt ID: (Human) P22888, (Rat) P16235, (Mouse) P30730

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Entrez Gene ID: (Human) 3973, (Rat) 25477, (Mouse) 16867

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Function(s)

luteinizing hormone receptor activity G-protein coupled peptide receptor activity choriogonadotropin hormone receptor activity choriogonadotropin hormone binding peptide hormone binding identical protein binding protein homodimerization activity ATPase binding signal transducer activity G-protein coupled receptor activity protein-hormone receptor activity

Process(es)

ovarian follicle development protein targeting to lysosome G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway spermatogenesis central nervous system development male gonad development female gonad development hormone-mediated signaling pathway positive regulation of calcium ion transport into cytosol ovulation cycle process positive regulation of inositol trisphosphate biosynthetic process response to drug luteinizing hormone signaling pathway positive regulation of cAMP-mediated signaling development of secondary male sexual characteristics positive regulation of hormone biosynthetic process arachidonic acid secretion regulation of steroid biosynthetic process positive regulation of calcium-mediated signaling cognition positive regulation of release of sequestered calcium ion into cytosol uterus development cellular response to gonadotropin stimulus seminiferous tubule development regulation of steroid hormone biosynthetic process G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G-protein coupled receptor signaling pathway male genitalia development signal transduction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LHCGR Polyclonal Antibody

LHCGR Antibody (19968-1-AP) in WB

Product Details

19968-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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