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Product Details
MA5-15876
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5G7
Immunogen
Purified recombinant fragment of human PINCH expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11154012
Product Specific Information
MA5-15876 targets PINCH in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human samples.
The MA5-15876 immunogen is purified recombinant fragment of human PINCH expressed in E. Coli. .
MA5-15876 detects PINCH which has a predicted molecular weight of approximately 37kDa.
Target Information
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIM and senescent cell antigen-like domains 1; LIM and senescent cell antigen-like-containing domain protein 1; LIM-type zinc finger domains 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48; senescent cell antigen
Gene Aliases: LIMS1; PINCH; PINCH-1; PINCH1
UniProt ID: (Human) P48059
Entrez Gene ID: (Human) 3987
epithelial to mesenchymal transition
cell aging
positive regulation of gene expression
positive regulation of cell-substrate adhesion
cell junction assembly
positive regulation of GTPase activity
establishment of protein localization
negative regulation of transcription, DNA-templated
regulation of epithelial cell proliferation
positive regulation of focal adhesion assembly
cellular response to transforming growth factor beta stimulus
positive regulation of substrate adhesion-dependent cell spreading
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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