Proteintech

LIPA Polyclonal Antibody

LIPA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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LIPA Antibody (12956-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 12956-1-AP ( LIPA Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

12956-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LIPA Fusion Protein Ag3627 (15-200 aa encoded by BC012287)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: WPLHSEGSG GKLTALDPET NMNVSEIISY WGFPSEEYLV ETEDGYILCL NRIPHGRKNH SDKGPKPVVF LQHGLLADSS NWVTNLANSS LGFILADAGF DVWMGNSRGN TWSRKHKTLS VSQDEFWAFS YDEMAKYDLP ASINFILNKT GQEQVYYVGH SQGTTIGFIA FSQIPELAKR IKMFFAL (15-200 aa encoded by BC012287)

Target Information

This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Moderate Treadmill Exercise Alleviates NAFLD by Regulating the Biogenesis and Autophagy of Lipid Droplet.

Nutrients

Yang Y,Li X,Liu Z,Ruan X,Wang H,Zhang Q,Cao L,Song L,Chen Y,Sun Y

Sun Nov 20 00:00:00 UTC 2022

CircRNA-Associated ceRNA Network Reveals Focal Adhesion and Metabolism Pathways in Neuropathic Pain.

Journal of oncology

Wang K,Bao JP,Zhou ZM,Mao L,Wu XT

Wed Sep 07 00:00:00 UTC 2022

Morroniside, a novel GATA3 binding molecule, inhibits hepatic stellate cells activation by enhancing lysosomal acid lipase expression.

Phytomedicine : international journal of phytotherapy and phytopharmacology

An L,Zhang M,Lin Y,Jiang T,Xu K,Xiao S,Cai L,Kwan HY,Liu Z,Su T

Mon Aug 01 00:00:00 UTC 2022

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.

Cancer communications (London, England)

He L,Li H,Pan C,Hua Y,Peng J,Zhou Z,Zhao Y,Lin M

Sun Aug 01 00:00:00 UTC 2021

Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver.

Cell death & disease

Carotti S,Lettieri-Barbato D,Piemonte F,Ruggiero S,Rosina M,Zalfa F,Zingariello M,Arciprete F,Valentini F,Francesconi M,D'Amico J,De Vincentis A,Baiocchini A,Perrone G,Antonelli-Incalzi R,Morini S,Picardi A,Aquilano K,Vespasiani-Gentilucci U

Thu Nov 18 00:00:00 UTC 2021

Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver.

Cell death & disease

Thu Nov 18 00:00:00 UTC 2021

Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver.

Cell death & disease

Thu Nov 18 00:00:00 UTC 2021

Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver.

Cell death & disease

Thu Nov 18 00:00:00 UTC 2021

Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver.

Cell death & disease

Thu Nov 18 00:00:00 UTC 2021

Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver.

Cell death & disease

Thu Nov 18 00:00:00 UTC 2021

Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver.

Cell death & disease

Thu Nov 18 00:00:00 UTC 2021

Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver.

Cell death & disease

Thu Nov 18 00:00:00 UTC 2021

Evidence for a Novel Regulatory Interaction Involving Cyclin D1, Lipid Droplets, Lipolysis, and Cell Cycle Progression in Hepatocytes.

Hepatology communications

Wu H,Ploeger JM,Kamarajugadda S,Mashek DG,Mashek MT,Manivel JC,Shekels LL,Lapiro JL,Albrecht JH

Fri Mar 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Acid cholesteryl ester hydrolase; cholesterol ester hydrolase; Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25; Cholesteryl esterase; Diacylglycerol lipase; Lipase A; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase; lysosomal acid lipase 1; lysosomal acid lipase A; Lysosomal acid lipase/cholesteryl ester hydrolase; pancreatic cholesterol esterase; RP11-341B24.1; Sterol esterase; Triacylglycerol ester hydrolase; Triacylglycerol lipase

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Gene Aliases: AA960673; CESD; Chole; Chole2; LAL; Lip-1; Lip1; LIPA

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UniProt ID: (Human) P38571, (Mouse) Q9Z0M5

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Entrez Gene ID: (Human) 3988, (Mouse) 16889, (Rat) 25055

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Function(s)

sterol esterase activity lipase activity hydrolase activity hydrolase activity, acting on ester bonds

Process(es)

cell morphogenesis cytokine production lipid metabolic process fatty acid metabolic process inflammatory response cell proliferation lipid catabolic process sterol metabolic process lung development tissue remodeling homeostasis of number of cells within a tissue

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LIPA Polyclonal Antibody

LIPA Antibody (12956-1-AP) in IHC (P)

Product Details

12956-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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