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Invitrogen
LIPC Polyclonal Antibody
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LIPC Antibody (PA5-78040) in IHC (P)
LIPC Polyclonal Antibody detects Hepatic lipase protein at cytoplasm in Hep G2 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded Hep G2 xenograft. LIPC Polyclonal Antibody (Product # PA5-78040) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-78040
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Hepatic lipase. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2736091
Product Specific Information
Positive Control: HepG2
Predicted Reactivity: Mouse (81%), Dog (82%), Pig (80%), Rabbit (82%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Lipase family belongs to one of the most robust genetic superfamilies found in living organisms that includes esterases and thioesterases. Lipase gene products are related by tertiary structure rather than primary amino acid sequence. Balancing the composition and the transport of lipoproteins in human plasma is essential for normal body function and is mediated in part by Hepatic Lipase, also known as HL or LIPC. Rare deficiencies in Hepatic Lipase have been identified in humans which lead to pathologic levels of circulating lipoprotein particles; this condition is associated with coronary artery disease (CAD). Hepatic Lipase is regulated by thyroid hormones and has a dual function as a triglyceride hydrolase and a ligand/bridging factor for receptor-mediated lipoprotein uptake. Hepatic Lipase localizes to the endothelial surfaces of extrahepatic tissues.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hepatic lipase; Hepatic triacylglycerol lipase; HL; Lipase member C; lipase, hepatic; Lysophospholipase; Phospholipase A1; Triacylglycerol lipase
Gene Aliases: HDLCQ12; HL; HTGL; LIPC; LIPH
UniProt ID: (Human) P11150
Entrez Gene ID: (Human) 3990
phospholipase activity
lysophospholipase activity
triglyceride lipase activity
heparin binding
lipid binding
phosphatidylcholine 1-acylhydrolase activity
transferase activity, transferring acyl groups
low-density lipoprotein particle binding
apolipoprotein binding
heparan sulfate proteoglycan binding
acylglycerol lipase activity
response to hypoxia
liver development
fatty acid biosynthetic process
phosphatidylserine metabolic process
circadian rhythm
cholesterol metabolic process
response to carbohydrate
response to acetate
heparan sulfate proteoglycan biosynthetic process
triglyceride catabolic process
response to nutrient levels
response to magnesium ion
cellular response to hormone stimulus
chylomicron remodeling
very-low-density lipoprotein particle remodeling
intermediate-density lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
chylomicron remnant clearance
low-density lipoprotein particle clearance
phosphatidylcholine catabolic process
response to drug
cholesterol homeostasis
response to amino acid
response to peptide hormone
reverse cholesterol transport
lipid digestion
phosphatidylethanolamine metabolic process
phosphatidic acid metabolic process
glycerophospholipid catabolic process
response to copper ion
developmental growth
protein oligomerization
response to glucocorticoid
response to calcium ion
triglyceride homeostasis
response to fatty acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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