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LMTK3 Antibody (PA5-101240) in IHC (P)
Immunohistochemistry analysis of LMTK3 in rat heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with LMTK3 polyclonal antibody (Product # PA5-101240) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-101240
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LMTK3(Accession Q96Q04), corresponding to amino acid residues R674-P724.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850681
Product Specific Information
Antibody detects endogenous levels of total LMTK3.
Target Information
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis-associated tyrosine kinase 3; KIAA1883; Lemur tyrosine kinase 3; protein phosphatase 1, regulatory subunit 101; Serine/threonine-protein kinase LMTK3; similar to 5E5 antigen
Gene Aliases: Aatyk3; BC059845; LMR3; Lmtk3; PPP1R101; TYKLM3
UniProt ID: (Mouse) Q5XJV6
Entrez Gene ID: (Human) 114783, (Rat) 691056, (Mouse) 381983
Performance Guarantee
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