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Invitrogen
LMX1B Polyclonal Antibody
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LMX1B Antibody (PA5-89579) in WB
Western blot analysis of LMX1B in extracts of various cell lines. Samples were incubated with LMX1B Polyclonal antibody (Product # PA5-89579) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-89579
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LMX1B (NP_0011676181)
Conjugate
Form
Liquid
Concentration
1.03 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805665
Product Specific Information
Immunogen sequence: MDIATGPESL ERCFPRGQTD CAKMLDGIKM EEHALRPGPA TLGVLLGSDC PHPAVCEGCQ RPISDRFLMR VNESSWHEEC LQCAACQQAL TTSCYFRDRK; Positive Samples: BT474, BxPC3, HeLa, Mouse liver, Mouse heart, Rat brain; Cellular Location: Nucleus
Target Information
LMX1B, LIM homeobox transcription factor 1B, belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1B regulates mid-hindbrain patterning LMX1B-null mice embryos have a severe reduction in the number of midbrain dopaminergic neurons compared to wild-type. While LMX1B appears to be important for both the development and the survival of dopamine neurons, the related LMX1A is crucial for the differentiation of these cells. However, LMX1A and LMX1B function cooperatively to regulated the proliferation, specification and differentiation of midbrain dopaminergic neuronal progenitors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIM homeo box transcription factor 1B; LIM homeobox transcription factor 1 beta; LIM homeobox transcription factor 1, beta; LIM homeobox transcription factor 1-beta; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B; LMX-1.2
Gene Aliases: LMX1.1; LMX1.2; LMX1B; NPS1
UniProt ID: (Human) O60663, (Mouse) O88609
Entrez Gene ID: (Human) 4010, (Rat) 114501, (Mouse) 16917
in utero embryonic development
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
dorsal/ventral pattern formation
neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
dopaminergic neuron differentiation
neuron migration
trabecular meshwork development
regulation of transcription from RNA polymerase II promoter
biological_process
cell proliferation
regulation of gene expression
cerebellum morphogenesis
central nervous system neuron development
collagen fibril organization
midbrain development
limb morphogenesis
organ growth
camera-type eye development
embryonic limb morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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