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Invitrogen
LNPEP Polyclonal Antibody
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LNPEP Antibody (PA5-88277) in IHC (P)
Immunohistochemistry analysis of LNPEP in paraffin-embedded human placenta. Samples were incubated with LNPEP Polyclonal antibody (Product # PA5-88277) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-88277
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human LNPEP (NP_0055662)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2804794
Product Specific Information
Immunogen sequence: MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG SRLLVRGLGE HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD GACSVPSART; Positive Samples: 293T, HT-29, U-87MG, HeLa, Jurkat, Mouse heart, Rat heart; Cellular Location: Cell membrane, Single-pass type II membrane protein
Target Information
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aminopeptidase Vp165; angiotensin IV receptor; AT (4) receptor; Cystinyl aminopeptidase; GP160; insulin-regulated aminopeptidase; Insulin-regulated membrane aminopeptidase; insulin-regulated membrane aminopeptidase IRAP; Insulin-responsive aminopeptidase; IRAP; Leucyl-cystinyl aminopeptidase; leucyl/cystinyl aminopeptidase; OTase; Oxytocinase; P-LAP; Placental leucine aminopeptidase; vasopressinase; Vesicle protein of 165 kDa; vp160; Vp165
Gene Aliases: 2010309L07Rik; 4732490P18Rik; CAP; gp160; IRAP; LNPEP; OTASE; P-LAP; PLAP; Vp165
UniProt ID: (Human) Q9UIQ6, (Rat) P97629, (Mouse) Q8C129
Entrez Gene ID: (Human) 4012, (Rat) 171105, (Mouse) 240028
proteolysis
response to hormone
neuropeptide catabolic process
protein catabolic process
angiotensin-activated signaling pathway
peptide catabolic process
positive regulation of blood pressure
regulation of long-term neuronal synaptic plasticity
SMAD protein signal transduction
protein polyubiquitination
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
signal transduction
cell-cell signaling
female pregnancy
regulation of blood pressure
membrane organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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