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Abnova
LOC63929 Polyclonal Antibody, MaxPab™
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Product Details
H00063929-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LOC63929 (NP_071381, 1 a.a. approximately 507 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI QRLRLIKSPA EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV TQDSPLILSA DCPKEMNDIE QICSQAS
Target Information
XPNPEP3, also known as X-Prolyl Aminopeptidase 3, is a gene located on chromosome 22q that encodes an enzyme involved in the processing of mitochondrial matrix proteins. The enzyme is classified under the M24B subfamily of metallopeptidases, which specifically remove the N-terminal amino acid from oligopeptides where the penultimate residue is proline. XPNPEP3 is implicated in conditions such as cystic kidney disease and participates in TNF-TNFR2 cellular signaling pathways. Its yeast and plant homologs, like Icp55, perform similar functions by stabilizing proteins after import into the mitochondrial matrix. Mutations in XPNPEP3 are associated with defects in ciliary structure and function, contributing to the phenotypic spectrum seen in nephronophthisis-related ciliopathies (NPHP-RCs). The crystal structure of XPNPEP3 has been resolved at 1.65 A resolution, revealing its interaction with inhibitors such as apstatin. Furthermore, XPNPEP3 is identified as a transcriptional target of the canonical Wnt/beta-catenin signaling pathway, with elevated transcript levels observed in tumors exhibiting activated Wnt signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aminopeptidase P3; APP3; Intermediate Cleaving Peptidase 55; X-Pro aminopeptidase 3; X-prolyl aminopeptidase (aminopeptidase P) 3, putative; X-prolyl aminopeptidase 3, mitochondrial; Xaa-Pro aminopeptidase 3
Gene Aliases: APP3; ICP55; NPHPL1; XPNPEP3
UniProt ID: (Human) Q9NQH7
Entrez Gene ID: (Human) 63929
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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