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Product Details
MA5-49085
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
23C11
Immunogen
Fusion protein of extracellular domain (aa 71-273) of human LOX-1 with murine Fc-gamma1 (LOX-1-muFc) produced in PEAK cells
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Purification
Protein G
Storage buffer
PBS with 1% BSA
Contains
0.02% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3093275
Product Specific Information
Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.
Target Information
LOX-1 (lectin-like oxidized LDL receptor -1) is a 40-50 kDa type II membrane glycoprotein class E scavenger receptor expressed by endothelial cells, macrophages, activated platelets and smooth muscle cells. LOX-1 binds to a wide range of ligands, including oxidized low-density lipoprotein (oxLDL), hypochlorite modified high-density lipoprotein (HDL), aged /apoptotic cells, activated platelets and bacteria, reflecting its versatile physiological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-type lectin domain family 8 member A; hLOX 1; hLOX-1; hLOX1; Lectin-like oxidized LDL receptor 1; Lectin-type oxidized LDL receptor 1; LOX 1; LOX-1; ox LDL receptor 1; Ox-LDL receptor 1; oxidized low density lipoprotein (lectin-like) receptor 1; Oxidized low-density lipoprotein receptor 1; oxidized low-density lipoprotein receptor 1, soluble form; scavenger receptor class E, member 1; sLOX 1; soluble LOX 1
Gene Aliases: CLEC8A; LOX1; LOXIN; OLR1; SCARE1; SLOX1
UniProt ID: (Human) Q2PP00
Entrez Gene ID: (Human) 4973
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