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Invitrogen
LOX Recombinant Rabbit Monoclonal Antibody (9K10Z3)
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LOX Antibody (MA5-35123) in IHC (P)
Immunohistochemistry analysis of LOX in paraffin-embedded human colon. Samples were incubated with LOX Monoclonal antibody (Product # MA5-35123) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
MA5-35123
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
9K10Z3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 318-417 of human LOX (P28300)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849028
Product Specific Information
Immunogen sequence: GHKASFCLED TSCDYGYHRR FACTAHTQGL SPGCYDTYGA DIDCQWIDIT DVKPGNYILK VSVNPSYLVP ESDYTNNVVR CDIRYTGHHA YASGCTISPY
Target Information
Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lysyl oxidase; Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts); MGC105112; Protein-lysine 6-oxidase; Ras excision protein; ras recision
Gene Aliases: AI893619; H-rev142; LOX; Rrg; Rrg1; TSC-160
UniProt ID: (Human) P28300, (Mouse) P28301
Entrez Gene ID: (Human) 4015, (Rat) 24914, (Mouse) 16948
blood vessel development
response to hormone
collagen fibril organization
lung development
wound healing
response to drug
elastic fiber assembly
response to steroid hormone
oxidation-reduction process
cellular protein modification process
heart development
extracellular matrix organization
aorta development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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