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Invitrogen
LOXL2 Recombinant Rabbit Monoclonal Antibody (JU32-53)
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FIGURE: 1 / 8
LOXL2 Antibody (MA5-41242) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of LOXL2 in HUVEC cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with LOXL2 Recombinant Monoclonal Antibody (Product # MA5-41242) at a dilution of 1:50 for 1 hour at room temperature, washed with PBS. Alexa Fluor®488 Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is DAPI (blue).
Product Details
MA5-41242
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JU32-53
Immunogen
Synthetic peptide within C-terminal human LOXL2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898995
Target Information
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lysyl oxidase homolog 2; lysyl oxidase related 2; lysyl oxidase-like 2 delta e13; lysyl oxidase-like 2 protein; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14
Gene Aliases: 1110004B06Rik; 4930526G11Rik; 9430067E15Rik; LOR2; LOXL2; WS9-14
UniProt ID: (Human) Q9Y4K0, (Mouse) P58022, (Rat) B5DF27
Entrez Gene ID: (Human) 4017, (Mouse) 94352, (Rat) 290350
chromatin binding
transcription corepressor activity
protein-lysine 6-oxidase activity
scavenger receptor activity
copper ion binding
protein binding
electron carrier activity
methylated histone binding
oligosaccharide binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
metal ion binding
response to hypoxia
epithelial to mesenchymal transition
endothelial cell proliferation
sprouting angiogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular protein modification process
chromatin modification
histone modification
protein deamination
collagen fibril organization
positive regulation of chondrocyte differentiation
endothelial cell migration
negative regulation of transcription, DNA-templated
response to copper ion
oxidation-reduction process
receptor-mediated endocytosis
cell adhesion
aging
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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