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MA5-15474 targets LPA in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.
The MA5-15474 immunogen is purified recombinant fragment of LPA (4330-4521) expressed in E. Coli.
The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: antiangiogenic AK38 protein; Apo(a); Apolipoprotein(a); lipoprotein, Lp(a); lp(a)
Gene Aliases: AK38; APOA; LP; LPA
UniProt ID: (Human) P08519
Entrez Gene ID: (Human) 4018
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